多维表观遗传钟证明精神分裂症的生理系统加速衰老:一个元分析
medRxiv : the preprint server for health sciences
|November 22, 2024
概括
多维表观遗传钟揭示了精神分裂症患者多个器官系统的加速衰老. 这项研究强调了心脏,肺部,代谢和大脑衰老的风险增加,为疾病机制提供了新的见解.
科学领域:
- 精神病学是一个精神病学.
- 遗传学 是一个遗传学.
- 衰老研究研究 衰老研究
背景情况:
- 精神分裂症与加速衰老,增加发病率和死亡率有关.
- 之前的研究使用了一维的表观遗传钟,限制了对衰老过程的细粒度洞察力.
研究的目的:
- 用新型的多维表观遗传钟来分析精神分裂症中的生物衰老.
- 为了获得机械洞察力,了解精神分裂症,表观遗传衰老和健康结果之间的关系.
主要方法:
- 一个对7个横截面数据集的元分析,包括1891名精神分裂症患者和1881名对照.
- 对多维表观遗传时钟的分析:原因年龄,系统年龄,复原元素年龄,DNAmEMRAge和OMICmAge.
- 研究了与精神分裂症状态和克洛扎使用的关联,对年龄和性别进行控制.
主要成果:
- 多维时钟 (SystemsAge,CausAge,DNAmEMRAge,OMICmAge) 显示精神分裂症的表观遗传衰老加速.
- 十个系统年龄分钟表明衰老加快,特别是在心脏,肺部,新陈代谢和大脑系统.
- OMICmAge揭示了血液学,肝脏标记物和新型蛋白质/代谢物的变化;在第一次精神病发作时观察到年龄加速.
结论:
- 这项研究首次分析了精神分裂症患者的多维时钟,为老化提供了细微的观点.
- 识别了多个器官系统 (心脏,肺,新陈代谢,大脑) 在精神分裂症相关疾病的高风险.
- 提供了对精神分裂症,表观遗传衰老和过早发病/死亡之间的机制联系的新见解.
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