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在污染较小的地区,颗粒物暴露与急性缺血性中风入院之间的关联:使用分布式滞后非线性模型进行时间序列研究

Xiaoxiao Song¹, Xiaolan Huang², Jinling Li¹

¹Guangxi University of Chinese Medicine, Nanning, Guangxi China.

Journal of environmental health science & engineering

|November 22, 2024

概括

在一般人群中,短期暴露于颗粒物 (PM) 与急性缺血性中风 (AIS) 住院病例无关. 然而,男性和65岁以下的成年人被发现更容易暴露在PM中,这凸显了针对性干预的必要性.

科学领域:

环境健康环境健康
流行病学流行病学
心血管疾病研究研究

背景情况:

缺血性中风 (IS) 在中国构成了重大公共卫生挑战.
在污染较小的地区,关于颗粒物 (PM) 和急性缺血性中风 (AIS) 之间的关联存在有限的研究,结果不一致.
这项研究解决了在空气污染水平较低的地区对PM暴露和AIS住院治疗的局部数据的需求.

研究的目的:

调查短期暴露于颗粒物 (PM) 和急性缺血性中风 (AIS) 的住院治疗之间的关联.
为了评估南宁的这种关系,南宁是一个空气污染相对较低的地区.
识别潜在的敏感人群,包括按年龄和性别分类.

主要方法:

采用时间序列研究设计,使用2017年7月1日至2020年6月30日的每日数据.
数据包括因AIS住院,环境空气污染 (PM2.5,PM10和PMc) 和气象因素.
用分布式滞后非线性模型 (DLNM) 来分析这些关联,对年龄和性别进行分层分析.

主要成果:

在研究期间,共记录了2382例AIS住院病例.
在一般人群中,总体颗粒物暴露和AIS入院之间没有发现显著的关联.
亚组分析显示PM2.5,PM10和PMc暴露与男性AIS入院之间的显著关联,以及65岁以下的个体的PMc暴露.

结论:

在南宁的一般人口中,短期环境PM暴露与AIS住院并无关联.
男人和年轻成年人 (65岁以下) 代表了易受脆弱的子组,容易受到颗粒暴露对AIS的影响.
建议采取有针对性的公共卫生干预措施,以减轻空气污染对这些易受污染群体的不利影响,即使是在污染水平较低的地区.

关键词:

急性缺血性中风是一次急性缺血性中风.DLNM DLNM DLNM DLNM DLNM 在线医院的入院情况污染较少的地区颗粒物质是颗粒物质中的一种.

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