长期COVID的神经表现不成比例地影响年轻和中年成年人
Natasha A Choudhury1, Shreya Mukherjee1, Tracey Singer1
1Davee Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL.
Annals of neurology
|November 22, 2024
概括
年轻和中年成人在COVID-19后经历了较高的神经症状和认知功能障碍的负担,影响了他们的生活质量. 老年人表现出更多的神经学发现,但长期症状较少.
科学领域:
- 神经学 神经学
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- SARS-CoV-2 感染 (Neuro-PASC) 后急性后续影响个人一生.
- 了解Neuro-PASC中与年龄相关的差异对于公共健康至关重要.
- 神经学表现在住院和非住院COVID-19幸存者之间有所不同.
研究的目的:
- 为了研究与年龄相关的神经症状表现的神经-PASC.
- 在住院后 (PNP) 和非住院 (NNP) 患者中比较神经PASC.
- 评估Neuro-PASC对不同年龄组生活质量的影响.
主要方法:
- 在200名PNP和1,100名NNP患者的横截面研究中.
- 患者分为年轻人 (18-44岁),中年人 (45-64岁) 和老年人 (65岁以上) 组.
- 评估并发症,神经学发现,症状,疲劳,睡眠障碍,执行功能和工作记忆.
主要成果:
- 年轻和中年人群占PNP (71%) 和NNP (90.5%) 患者的大多数.
- 老年患者的并发病率和神经系统异常发现率更高.
- 年轻和中年NNP患者报告了更高的疲劳,睡眠障碍和认知功能障碍 (执行功能,工作记忆),导致生活质量下降.
结论:
- 年轻和中年成人不成比例地受到Neuro-PASC症状和认知功能障碍的影响.
- 尽管神经学发现更频繁,但老年人经历的症状负担较低.
- 神经PASC显著影响成年人处于最佳状态,需要有针对性的公共卫生资源.
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