大麻吸入对动脉硬,血管内皮功能和心脏功能的急性影响
Christian P Cheung1, Alexandra M Coates1, Ryleigh E Baker1
1Human Health and Nutritional Sciences University of Guelph Canada.
Journal of the American Heart Association
|November 22, 2024
概括
主要含有四大麻 (THC) 的大麻会急剧增加心率和血压,可能会损害动脉硬性和扩张功能. 大麻中大多含有大麻二醇 (CBD),但没有表现出这些心血管影响.
科学领域:
- 心血管科学 心血管科学
- 药理学 药理学是指药理学的学科.
- 大麻素研究 研究 大麻素研究
背景情况:
- 大麻使用对心血管的影响尚未完全理解,特别是对亚临床功能障碍的急性影响.
- 关于吸入方法和大麻素特征如何影响心血管风险的研究有限.
- 长期使用大麻与增加心血管疾病风险和不良事件有关.
研究的目的:
- 研究大麻吸入对动脉硬,血管内皮反应能力和心脏功能的急性心血管影响.
- 为了确定吸入方法 (吸烟与蒸发) 和大麻素特征 (THC与CBD占主导地位) 是否会改变这些急性影响.
- 为了确定急性大麻暴露后心血管功能障碍的标志物.
主要方法:
- 评估了22名健康的年轻大麻使用者.
- 测量包括脉冲波速度 (动脉硬度),臂动脉流介导扩张 (内皮功能) 和心声图 (心脏功能).
- 参与者在吸烟THC占主导地位的大麻,蒸发THC占主导地位的大麻和蒸发CBD占主导地位大麻后进行了评估.
主要成果:
- 主要含有THC的大麻 (吸烟和蒸发) 显著增加了心率和平均动脉压.
- 蒸发CBD占主导地位的大麻并没有显著改变心率或血压.
- 脉冲波速度增加,在THC占主导地位的大麻吸入后,无论使用何种方法,腹筋功能下降.
- 心率的变化与动脉硬和心动功能变化相关.
结论:
- 含有THC的大麻会急剧增加心率和血压,无论吸入方法如何.
- 这些效应与动脉硬度增加和扩张功能降低有关.
- 大麻中大麻二醇占主导地位似乎不会引起这些急性心血管变化,这意味着THC是大麻相关心血管功能障碍的关键因素.
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