艾滋病毒相关心力衰竭:在安全网设置中的表型和临床结果
Matthew S Durstenfeld1, Anjali Thakkar2, Diane Jeon2
1Division of Cardiology at ZSFG and Department of Medicine University of California, San Francisco (UCSF) San Francisco CA USA.
Journal of the American Heart Association
|November 22, 2024
概括
被诊断为心力衰竭 (HF) 的艾滋病毒感染者面临更高的死亡率,通常是由于使用物质等非心血管原因. 这项研究强调了安全网系统内高频护理的差异.
科学领域:
- 心脏病学 心脏病学
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 艾滋病毒感染是心力衰竭 (HF) 的已知危险因素.
- 在安全网系统中,关于艾滋病毒感染者 (PWH) 的HF表型和结果的数据有限.
- 安全网系统在美国照顾着大量的PWH.
研究的目的:
- 为了比较HF表型,死亡率和PWH死亡原因与没有艾滋病毒的人.
- 在一个大型市政安全网系统中调查高频结果.
- 了解在缺乏资源的医疗保健机构中,PWH患有HF所面临的具体挑战.
主要方法:
- 对电子健康记录队列 (2001-2019) 的HF患者的回顾性分析.
- 将电子健康记录数据与国家死亡指数加 (National Death Index Plus) 联系起来,以获得死亡结果.
- 对比HF表型,全因死亡率,HF住院和PWH和艾滋病毒未感染个体之间的死亡原因.
主要成果:
- 平均而言,PWH被诊断出HF的年龄小于10岁,并且射出分数减少的比例更高.
- 艾滋病毒与全因死亡率 (HR 1.55) 的风险增加55%和HF住院的几率降低 (OR 0.51) 相关.
- 患有高血压的PWH患者的死亡原因不太常是心血管疾病,更常被归因于物质使用.
结论:
- 在安全网系统中,艾滋病毒感染与HF患者的死亡率显著增加有关.
- 尽管HF住院率较低,但患有HF的PWH的生存率更差.
- 非心血管原因,包括物质使用和与艾滋病毒有关的疾病,导致该人口的过度死亡率.
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