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血管内皮生长因子和内动脉瘤的发病:复杂途径中缺失环节的系统审查

Peyton L Nisson^1,2, Michael T Lawton¹, Oscar Cisneros¹

¹Departments of Neurosurgery, Barrow Aneurysm and AVM Research Center, and Translational Neuroscience, Barrow Neurological Institute St. Joseph's Hospital and Medical Center Phoenix AZ USA.

Journal of the American Heart Association

|November 22, 2024

概括

血管内皮生长因子 (VEGF) 在内动脉瘤中表达高,这表明它在疾病发展中的作用. 对VEGF的进一步研究对于了解动脉瘤病理生理学和潜在的治疗方法至关重要.

科学领域:

神经科学是一个神经科学.
血管生物学血管生物学
遗传学是一个遗传学.

背景情况:

内动脉瘤是目前没有医疗治疗的脑血管疾病的重要原因.
动脉瘤的复杂病理生理学仍然不完全理解.
血管内皮生长因子 (VEGF) 越来越多地与动脉瘤的发展和破裂有关.

研究的目的:

审查目前关于血管内皮生长因子 (VEGF) 与内动脉瘤之间的关系的证据.
探索VEGF在动脉瘤病理生理学中的作用.
评估VEGF作为潜在的治疗点.

主要方法:

按照PRISMA的指导方针,在主要数据库 (PubMed,Cochrane图书馆,Web of Science,Google Scholar) 中进行了系统的文献搜索.
纳入标准侧重于人类和动物研究,调查内动脉瘤与VEGF之间的联系.
进行了数据提取和合成,以分析发现.

主要成果:

在内动脉瘤组织,脑脊液,以及在人体和动物模型中系统观察到VEGF表达升高.
过度表达VEGF证明了对内皮细胞迁移和增殖的抑制作用,并诱导了亡.
发现VEGF的遗传多态性与内动脉瘤的存在有显著的相关性.

结论:

虽然尚未确定确定的因果关系,但大量证据支持VEGF参与动脉瘤病理生理学.
VEGF代表了未来对动脉瘤发育的研究的一个有希望的途径.
VEGF被确定为内动脉瘤的潜在治疗标.

关键词:

大脑动脉瘤是什么?大脑动脉瘤是什么意思头骨内动脉瘤是什么意思病理生理学病理生理学系统性审查系统性审查血管内皮生长因子血管内皮生长因子

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