炎症指数及其与术后狂妄症的关联
Gabrielle E Mintz1, Edward R Marcantonio2,3, Jeremy D Walston4
1Department of Medicine, University of Arizona College of Medicine, Tucson, Arizona, USA.
概括
一个加权的炎症指数,结合多个生物标志物,显示了与术后妄想比单个标志物更强烈的关联. 这种多蛋白质指数可以改善老年手术患者的妄想风险预测.
科学领域:
- 老年医学 老年医学
- 手术瘤学手术瘤学
- 炎症性疾病 炎症性疾病
背景情况:
- 炎症与 Delirium 病原发生有关,而个别生物标志物先前与其发生有关.
- 目前还没有研究将炎症生物标志物聚合到一个指数中,以评估它们对妄想的预测价值.
研究的目的:
- 调查新型多蛋白质炎症指数与经历重大非心脏手术的老年人 Delirium 的发生率之间的关联.
主要方法:
- 四个炎症标志物 (CRP,IL-6,sTNFR1,CHI3L1) 在548名患者 (70岁以上) 的术前和术后测量.
- 计算了四个炎症指数:四分位数总结,加权总结,主要成分和LASSO衍生.
- 用混乱评估方法和图表审查来评估妄想;通用线性模型分析了关联.
主要成果:
- 权重总结得分显示,与妄想发病率的关联最强.
- 较高的加权总结分数四分位数与妄风险增加相关 (术前RR3.07,术后RR2.65).
- 在预测痴呆症方面,加权总结得分优于CHI3L1和IL-6等单个标志物.
结论:
- 多蛋白质炎症指数,特别是加权总结得分,在预测狂妄症时比单个标志物略有优势.
- 这种加权指数可能有助于识别患有术后狂妄症风险较高的患者.
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