一个快速发展的治疗景观.
Khalil Anchouche1,2, George Thanassoulis3,4
1McGill University Health Centre and Research Institute, Montréal, Québec, Canada.
Current atherosclerosis reports
|November 22, 2024
概括
针对高脂蛋白 (Lp[a]) 的新疗法正在开发中. 这些有前途的治疗方法旨在降低Lp[a]水平,解决显著的,未减轻的心血管风险因素.
科学领域:
- 心血管医学 心血管医学
- 药理学 药理学是指药理学的学科.
- 遗传学 遗传学 是一个
背景情况:
- 升高的脂蛋白a (Lp[a]) 是动脉样硬化冠状动脉疾病和大动脉狭窄症的遗传决定性风险因素.
- Lp[a]是普遍存在的,促使推进行普遍的成年人查.
- 目前,没有特定的Lp[a]降低药物被批准用于临床使用.
研究的目的:
- 审查药物开发管道中的新兴Lp[a]降低疗法.
- 讨论这些新型治疗方法的潜在未来临床应用.
主要方法:
- 对正在进行的新型Lp[a]降低疗法的第三期临床试验的审查.
- 针对LPA mRNA降解的基于RNA的治疗方法的描述.
- 关于早期药物开发候选药物的概述.
主要成果:
- 佩拉卡森和奥尔帕西兰是以RNA为基础的治疗方法,在第三阶段试验中,降解LPAmRNA.
- 其他候选人,如Lepodisiran,Zerlasiran和Muvalaplin正处于早期开发阶段.
- 目前没有Lp[a]降低药物得到批准,但有前途的候选药物正在调查中.
结论:
- 基于RNA的新型疗法显示出降低脂蛋白的潜力.
- 成功的临床试验可以为这种心血管风险因素提供第一个治疗方法.
- 这些疗法可能会显著扩大心血管护理选择.
相关概念视频
Drug Therapy
39
The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications
Antianxiety Medications
39
Drug Administration and Therapy Phases: Overview
409
Drugs, the chemical agents used in diagnosing, treating, or preventing diseases, undergo a four-phase process of development: pharmaceutic, pharmacokinetics, pharmacodynamics, and therapeutic.
The pharmaceutical phase focuses on leveraging the physicochemical properties of the drug to design and manufacture an effective product. Variants include orally administered tablets or capsules, topical creams or ointments, and parenteral-delivery solutions or emulsions.
The pharmacokinetic phase...
The pharmaceutical phase focuses on leveraging the physicochemical properties of the drug to design and manufacture an effective product. Variants include orally administered tablets or capsules, topical creams or ointments, and parenteral-delivery solutions or emulsions.
The pharmacokinetic phase...
409
Psychotherapy
77
Psychotherapy is a versatile, nonmedical approach aimed at helping individuals address emotional, behavioral, and interpersonal issues to enhance their overall well-being. It can involve one-on-one sessions, couples counseling, or small group discussions with a therapist. The therapeutic process includes various techniques such as open discussion, interpretation of thoughts and behaviors, active listening, positive reinforcement, and role modeling. Psychotherapy aims to support individuals in...
77
Healthcare Agencies II
689
There are various healthcare agencies in the United States—some of which are managed by religious institutions and others by different government branches.
Parish nursing is a growing specialty nursing profession that focuses on holistic healthcare, health promotion, and illness prevention. It blends professional nursing practice with a health ministry, focusing on health and healing within the context of a Christian community. Parish nurses serve as health educators, referral sources,...
Parish nursing is a growing specialty nursing profession that focuses on holistic healthcare, health promotion, and illness prevention. It blends professional nursing practice with a health ministry, focusing on health and healing within the context of a Christian community. Parish nurses serve as health educators, referral sources,...
689
Local Anesthetics: Clinical Application as Epidural Anesthesia
413
Epidural anesthetics are administered in the fat-filled epidural space, the outermost part of the spinal canal. This technique is commonly employed for pain management and anesthesia during lower abdomen and pelvis surgeries or labor and delivery.
Since epidural anesthetics can be infused through an epidural catheter, all types of drugs, including short-acting ones, can be administered. Chloroprocaine and lidocaine are examples of short and long-duration anesthetics, respectively. Bupivacaine...
Since epidural anesthetics can be infused through an epidural catheter, all types of drugs, including short-acting ones, can be administered. Chloroprocaine and lidocaine are examples of short and long-duration anesthetics, respectively. Bupivacaine...
413
Local Anesthetics: Pharmacokinetics
733
The potency and duration of action of local anesthetics (LAs) are determined by their pharmacokinetics. Pharmacokinetics describes how LAs are absorbed, distributed, metabolized, and eliminated from the body. When administered to the vascular tissues, LAs are quickly absorbed and enter the systemic circulation, reducing their localized effects. Adding vasoconstrictors such as epinephrine to LAs reduces their absorption into the systemic circulation, making them clinically effective. The...
733


