肥胖作为神经病变的危险因素:一个病例控制研究
Esra Ersan Tomo1, Hacer Hicran Mutlu2, Hasan Hüseyin Mutlu3
1Department of Family Medicine, Faculty of Medicine, Istanbul Medeniyet University, Istanbul, Turkey.
概括
代谢健康的肥胖个体与非肥胖的人相比,神经病变的患病率和严重程度明显更高. 这一发现突显了肥胖症中神经病变风险的增加,即使没有代谢功能障碍.
科学领域:
- 内分泌学和新陈代谢学
- 神经学 神经学
- 公共卫生 公共卫生
背景情况:
- 神经病变是一种常见的糖尿病并发症,与代谢障碍有关.
- 在有或没有肥胖的新陈代谢健康个体中神经病变的患病率尚不清楚.
- 肥胖是一个日益严重的全球健康问题,可能与神经系统并发症有关.
研究的目的:
- 为了比较新陈代谢健康的肥胖和非肥胖个体之间的神经病变的患病率和严重程度.
- 在代谢健康的队列中调查肥胖和神经病变之间的关联.
主要方法:
- 研究包括20-50岁的健康成年人,按BMI分类 (≥30 kg/m2肥胖者,<30 kg/m2非肥胖者).
- 排除标准是针对模仿或引起神经病变的疾病 (例如糖尿病,维生素B12缺乏症).
- 神经病症评估使用神经病症症状评分 (NSS) 和修改的神经病症残疾评分 (mNDS).
主要成果:
- 与非肥胖个体相比,在代谢上健康的肥胖个体表现出明显更高的NSS和mNDS得分 (p < 0.001).
- 肥胖与神经病变的可能性增加了110倍,并观察到更严重的严重程度.
- 在患有神经病变的参与者中,无论肥胖状况如何,都发现了较高的甘油三水平.
结论:
- 代谢健康的肥胖与神经病变的更高的患病率和严重程度有关.
- 肥胖可能独立地导致神经病变的发展,即使没有明显的代谢疾病.
- 对代谢健康的肥胖个体中神经病变的潜在机制进行进一步的研究是有必要的.
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