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相关概念视频

Classification of Epithelial Tissues: Overview01:22

Classification of Epithelial Tissues: Overview

Epithelial tissues are classified according to the shape of the cells and the number of cell layers formed. Cell shapes can be squamous (flattened and thin), cuboidal (square-like, as wide as it is tall), or columnar (rectangular, taller than it is wide). Additionally, the nucleus shape helps identify the type of epithelial cells. Squamous cells have flattened disc-shaped nuclei, cuboidal cells have spherical nuclei, and columnar cells have elongated nuclei.
Based on the number of cell layers,...
Classification of Epithelial Tissues: Stratified Epithelium01:29

Classification of Epithelial Tissues: Stratified Epithelium

Stratified epithelium consists of several stacked layers of cells. They provide the durability to withstand constant physical and chemical attacks. Stratified epithelium is named after the shape of the most apical layer of cells. Stratified squamous epithelium is the most common type found in the human body. In this tissue, the apical cells are squamous, whereas the basal layer contains either columnar or cuboidal cells. The basal cells divide to form new daughter cells, which gradually become...
Classification of Epithelial Tissues: Glandular Epithelium01:20

Classification of Epithelial Tissues: Glandular Epithelium

The glandular epithelium is made of one or more epithelial cells modified to synthesize and secrete chemical substances. Glandular epithelia can be classified based on cell number. Unicellular glands have individual secretory cells scattered across the epithelial monolayer. In contrast, multicellular glands consist of a hollow tubular duct attached to the cluster of secretory cells located in the deep pockets.
Multicellular glands are formed during early development when epithelial budding...
The Thyroid Gland01:23

The Thyroid Gland

The thyroid gland is a small, butterfly-shaped gland located in the neck and covers the anterior surface of the trachea. The gland has two lateral lobes connected by a thin tissue mass called the isthmus. Internally, each lobe comprises many small spherical structures known as thyroid follicles, surrounded by a network of blood vessels.
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...

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相关实验视频

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An Orthotopic Mouse Model of Anaplastic Thyroid Carcinoma
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对于甲状腺核针活检的简化四层分类.

M Paja1,2, J L Del Cura3,4, R Zabala5

  • 1Endocrinology Department, Hospital Universitario Basurto, OSI Bilbao-Basurto, Bilbao, Spain. miguel.pajafano@osakidetza.eus.

Journal of endocrinological investigation
|November 22, 2024
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概括

本研究引入了甲状腺结节核心针活检 (CNB) 的简化组织学分类,提供了明确的诊断类别和相关的恶性瘤风险. 拟议的系统显示了高精度和低率的不确定的结果,用于甲状腺癌诊断.

关键词:
核心针活组织检查诊断 诊断 诊断 诊断 诊断甲状腺癌是什么?甲状腺癌是什么?甲状腺结节 甲状腺结节

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科学领域:

  • 内分泌学 在内分泌学.
  • 病理学 病理学 病理学
  • 在瘤学瘤学.

背景情况:

  • 核针活检 (CNB) 是甲状腺结节的关键诊断工具.
  • 缺乏CNB标本的标准化组织学分类,这阻碍了一致的解释.
  • 现有的系统,如贝塞斯达系统精细针吸入细胞学 (FNAC),突出需要在CNB中进行类似的标准化.

研究的目的:

  • 建议对甲状腺结节CNB标本进行简化组织学分类.
  • 建立四个不同的诊断类别 (DC),确定恶性瘤 (ROM) 的风险和预期发病率.
  • 为了解决甲状腺结节诊断中CNB分类的统一方案的缺乏.

主要方法:

  • 追溯分析6284个来自单一机构的CNB,其中CNB是常规使用的.
  • 活检的分类为非诊断性,良性,卵泡瘤 (FT) 和恶性类别.
  • 与手术病理学的CNB发现的相关性,用于在活检后接受手术的结节.

主要成果:

  • 在6284个CNB中,9.7%是恶性的,6.9%被归类为卵泡瘤 (FT).
  • 对于接受手术的结节,良性瘤的恶性瘤 (ROM) 风险为2.2%,良性瘤的恶性瘤为12.4%,恶性瘤的恶性瘤为98.3%.
  • 在结合FT和恶性类别时,该分类实现了恶性瘤的高灵敏度 (94.7%) 和积极预测值 (65.6%).

结论:

  • 为甲状腺结节CNB提出的组织学分类表明了高的诊断准确性.
  • 该系统有效地减少了不确定的类别,提高了诊断清晰度.
  • 在西方实践中的应用显示了FT的低ROM,这表明免疫组织化学研究对改进有潜在的益处.