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68Ga-FAPI和18F-NaF在牛皮关节炎中的PET/CT:一项比较研究

Fan Yang^1,2, Chaofan Lu¹, Qingqing Pan³

¹Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing, China.

Rheumatology (Oxford, England)

|November 22, 2024

概括

加-68纤维细胞激活蛋白抑制剂 (68Ga-FAPI) PET/CT在牛皮关节炎 (PsA) 关节中的阳性率与-18化 (18F-NaF) PET/CT相比不同. 68Ga-FAPI PET/CT发现与PsA疾病活性相关.

科学领域:

核医学成像技术核医学成像技术
放射药学研究的研究.
类风湿病学类风湿病学

背景情况:

纤维细胞样同胞细胞激活和骨形成是牛皮关节炎 (PsA) 的关键.
像68Ga-纤维细胞激活蛋白抑制剂 (FAPI) 和18F-化物 (NaF) 这样的正子发射断层扫描 (PET) 标记物显示出检测PsA的潜力.
这项研究前性地评估了68Ga-FAPI PET/CT在PsA中的性能,并将其与18F-NaF PET/CT进行比较.

研究的目的:

评估68Ga-FAPI PET/CT在患有牛皮关节炎 (PsA) 的患者中的性能.
为了比较68Ga-FAPI PET/CT与18F-NaF PET/CT在PSA中的诊断效用.
评估PET发现与PsA临床疾病活性之间的相关性.

主要方法:

预期招收16名PSA参与者 (平均年龄为42.3岁).
使用68Ga-FAPI和18F-NaF的双追踪器PET/CT成像.
临床评估,超声波和PET阳性外周关节,内关节和轴关节病变的评分.

主要成果:

68Ga-FAPI PET/CT在外周关节 (21.84%) 的阳性比内关节 (12.15%) 和轴关节 (0%) 的阳性更高.
18F-NaF PET/CT在所有部位 (周边关节85.23%,内78.13%,轴关节75%) 显示出高阳性.
68Ga-FAPI PET/CT阳性与较高的DAS28得分和疾病活性指标相关 (疼痛/胀关节计数,DAS28-CRP,PASCAL,PsASon13),与18F-NaF PET/CT不同.

结论:

对于68Ga-FAPI和18F-NaF PET/CT的阳性率在PsA患者的外周关节,内关节和轴关节方面有所不同.
68Ga-FAPI PET/CT发现反映了关节参与,与PsA的临床变量和疾病活性得分有显著的相关性.
68Ga-FAPI PET/CT可能为PsA疾病负担和活动提供有价值的见解.

关键词:

纤维细胞激活蛋白质的激活蛋白质奥西辐射断层扫描/计算机断层扫描牛皮关节炎牛皮关节炎

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