微生物学和Staphylococcus aureus眼系统感染的管理:一个10年的回顾性研究
Niloufar Bineshfar1, Kevin D Clauss1, Wendy W Lee1
1Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, United States of America.
PloS one
|November 22, 2024
概括
常见的抗生素,如β-乳酸和基诺,在眼系统中对黄金葡萄球菌的疗效较低. 推使用trimethoprim/sulfamethoxazole和gentamicin作为有效的单剂治疗方法.
科学领域:
- 眼科医生 眼科 眼科
- 传染性疾病 传染性疾病
- 微生物学 微生物学
背景情况:
- 金色葡萄球菌,包括耐甲素 (MRSA) 和敏感 (MSSA) 菌株,可以引起眼系统感染.
- 经验性抗菌疗法经常用于这些感染,但其有效性需要评估.
研究的目的:
- 评估常见抗微生物药物对影响眼系统的MRSA和MSSA的体外有效性.
- 为了确定最佳的抗微生物选择实证治疗的眼 Staphylococcus aureus 感染.
主要方法:
- 从眼系统样本中分离116种金黄色菌的回顾性审查 (2013-2022年).
- 在体外抗微生物敏感性,临床特征和治疗结果的分析.
- 对各种抗生素类别的耐药率的评估,包括β-乳糖胺,诺,trimethoprim/sulfamethoxazole和 gentamicin.
主要成果:
- 44.8%的金黄色细菌分离物是MRSA.
- 对诺基诺 (西普洛素38.8%,莫西素30.4%) 观察到高的体外耐药率,特别是在MRSA中.
- 在trimethoprim/sulfamethoxazole (8.6%) 和 gentamicin (3.4%) 中发现了较低的抗药率.
结论:
- 通常处方的β-乳酸盐和化诺在体外对眼性黄金葡萄球菌的疗效有限.
- 推使用trimethoprim/sulfamethoxazole和gentamicin作为有效的全身和局部单剂治疗这些感染.
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