怀孕期间的结核菌菌感染:系统性审查
Alison J Morton1,2, Alexandra Roddy Mitchell3, Richard E Melville2
1Department of Infectious Diseases, The University of Melbourne, At the Peter Doherty Institute for Infection and Immunity, Melbourne, Australia.
PLOS global public health
|November 22, 2024
概括
怀孕会增加结核病 (TB) 的风险,特别是在老年妇女和高发病率地区的人群中. 周产期提供了查和安全的结核病预防治疗 (TPT) 的机会.
科学领域:
- 传染性疾病 传染性疾病
- 孕产妇健康 孕产妇健康
- 公共卫生 公共卫生
背景情况:
- 怀孕与感染Mycobacterium tuberculosis (Mtb) 的个体中患有活跃结核病 (TB) 的风险增加有关.
- 围产期是一个关键的窗口,用于在孕妇中针对Mtb感染的查和干预策略.
研究的目的:
- 系统地审查和综合现有的关于怀孕期间感染Mycobacterium结核病 (Mtb) 的文献.
- 分析孕妇群体中Mtb感染的患病率,自然史,诊断测试表现,护理级联和治疗结果.
主要方法:
- 在主要数据库 (Ovid MEDLINE,Embase,Web of Science,CENTRAL) 进行了全面的文献搜索,截至2023年10月3日.
- 纳入标准适用于47项选定的研究,这些研究检查了怀孕个体的Mtb感染.
主要成果:
- 结核病感染的发病率高达57.0%,老年妇女和来自高结核病发病率环境的妇女的发病率更高.
- 研究表明,在怀孕期间 (IRR 1.3-1.4) 和分娩后 (IRR 1.9-2) 从Mtb感染发展为活跃结核病的风险增加.
- 结核素皮肤测试 (TST) 和干扰素马释放试验 (IGRA) 显示出可变的一致性 (49.4%-96.3%). 结核病预防治疗 (TPT) 与没有重大不良事件相关.
结论:
- 产前期是Mtb感染查和治疗的可行机会,特别是优先考虑老年妇女和高发病率环境中的妇女.
- 结核病预防治疗 (TPT) 在怀孕期间似乎是安全和可行的,尽管需要进一步的研究来优化查和治疗算法.
更多相关视频
10:04Analysis of 18FDG PET/CT Imaging as a Tool for Studying Mycobacterium tuberculosis Infection and Treatment in Non-human Primates
Published on: September 5, 2017
18.8K
09:34An Automated Culture System for Use in Preclinical Testing of Host-Directed Therapies for Tuberculosis
Published on: August 16, 2021
1.8K
相关概念视频
Pulmonary Tuberculosis V
170
Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
170
Pulmonary Tuberculosis IV
133
Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
133
Pulmonary Tuberculosis I
220
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
220
Pulmonary Tuberculosis III
304
Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
The first classification is based on the development of the disease, and it includes the following categories:
304
Pulmonary Tuberculosis II
211
Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
211
