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Updated: Jun 6, 2025

Assaying the Kinase Activity of LRRK2 in vitro
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Published on: January 18, 2012

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CalDAG-GEFI作为LRRK2的关氨酸核酸交换因子,调节LRRK2功能和神经退行

Qinfang Liu1, Bingxu Huang1, Noah Guy Lewis Guiberson2,3

  • 1Department of Neuroscience, University of Connecticut School of Medicine, Farmington, CT 06030, USA.

Science advances
|November 22, 2024
PubMed
概括

研究人员确定了CalDAG-GEFI (CDGI) 作为氨酸丰富的重复激酶2 (LRRK2) GTPase活性的关键调节器. 这一发现为帕金森病提供了超越LRRK2激酶抑制的新治疗点.

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