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Updated: Jun 6, 2025

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在ADAR1编辑丢失后,GGNBP2调节由自我双链RNA触发的MDA5感应

Jacki E Heraud-Farlow1,2,3,4, Scott R Taylor1,3, Alistair M Chalk1

  • 1St. Vincent's Institute of Medical Research, Fitzroy, VIC 3065, Australia.

Science immunology
|November 22, 2024
PubMed
概括

GGNBP2,CNOT10和CNOT11通过MDA5.5调节细胞dRNA传感. GGNBP2的损失通过减少细胞质dRNA来防止I型IFN诱导和自身炎症,为ADAR相关疾病提供新的治疗点.

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