增加PUFA和蛋白质,减少碳水化合物摄入量改善12个月的肝脂肪和减肥作为调解者的作用:一个随机对照试验
Laura Pletsch-Borba1, Charlotte Wernicke2, Jürgen Machann3
1Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Endocrinology and Metabolism, 10117, Berlin, Germany; NutriAct-Competence Cluster Nutrition Research Berlin-Potsdam, Germany; Berlin Institute of Health at Charité - Universitätsmedizin Berlin, BIH Biomedical Innovation Academy, BIH Charité Junior Clinician Scientist Program, Berlin, Germany.
Clinical nutrition (Edinburgh, Scotland)
|November 22, 2024
概括
高蛋白质和不和脂肪酸摄入量,以及减少碳水化合物,在老年人中改善了肝内脂质 (IHL). 这些饮食变化,特别是多不和脂肪酸 (PUFA),对肝脏脂肪产生了积极的影响,部分独立于减肥.
科学领域:
- 营养科学 营养科学
- 代谢健康 代谢健康
- 肝脏疾病研究 肝脏疾病研究
背景情况:
- 以前的研究表明,不和脂肪酸 (UFA) 和蛋白质对肝脏内脂质 (IHL) 有积极影响.
- 此前,NutriAct试验已经在中年和老年人身上在12个月内证明了这些益处.
- 这项研究调查了IHL改善的特定宏观营养素驱动因素.
研究的目的:
- 为了确定特定的宏观营养成分,影响肝脏内脂质的减少.
- 分析蛋白质,不和脂肪酸和碳水化合物摄入量对IHL的影响.
- 探索BMI变化的作用和巨量营养素对IHL改善的直接影响.
主要方法:
- 从NutriAct随机对照试验 (n=502) 的数据分析.
- 包括具有IHL数据的参与者在基线和12个月内 (n=248).
- 线性回归和调解分析,以评估巨量营养素对IHL的影响,考虑到BMI变化.
主要成果:
- 干预组中合规的参与者表现出明显更大的IHL改善.
- 增加蛋白质和多不和脂肪酸 (PUFA) 摄入量,以及减少碳水化合物摄入量与IHL减少相关.
- IHL的改善部分是由BMI变化介导的,但PUFA摄入量也显示出直接的独立效应.
结论:
- 增加蛋白质摄入量和减少碳水化合物摄入量对IHL产生积极影响,其介于BMI变化.
- 更高的多不和脂肪酸 (PUFA) 摄入量有助于改善IHL,而不依赖于减肥.
- 这些发现阐明了长期饮食干预中对IHL的宏观营养素特异性影响.
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