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Updated: Jun 6, 2025

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在初级Sjogren综合征中,EZH2通过METTL3-介导的m6A修饰促进B细胞自身免疫

Yiying Yang1, Muyuan Li2, Liqing Ding3

  • 1Department of Rheumatology, Xiangya Hospital, Central South University, Changsha, Hunan, China; Department of Pathophysiology, School of Basic Medicine Science, Central South University, Changsha, Hunan, China; Sepsis Translational Medicine Key Lab of Hunan Province, Changsha, Hunan, China; Postdoctoral Research Station of Biology, School of Basic Medicine Science, Central South University, Changsha, Hunan, China.

Journal of autoimmunity
|November 22, 2024
PubMed
概括

增强性肠道同源2 (EZH2) 在初级Sjögren综合征 (pSS) B细胞中被上调,导致自身免疫反应. 抑制EZH2通过减少B细胞激活和自身抗体的产生,为pSS提供了一个有希望的治疗策略.

关键词:
这是一种B细胞自身免疫.在 EZH2 中使用.在METTL3中,METTL3是METTL3的第一个类型.m6A 一个很好的.在 pSS pSS 中.

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