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Updated: Jun 6, 2025

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突变负担和抗PD-1结果并不总是与免疫细胞透或淋巴细胞激活有关

David Hsiehchen1, Andrew Elliott2, Joanne Xiu2

  • 1Division of Hematology and Oncology, University of Texas Southwestern Medical Center, Dallas, TX, USA; Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX, USA.

Cancer cell
|November 22, 2024
PubMed
概括

免疫细胞透和基因特征并不总是预测患者对抗癌症免疫疗法的反应,例如抗PD-1/L1治疗. 这些免疫学标记在各种癌症中不能可靠地表明瘤免疫性和治疗成功.

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Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
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