母亲的维生素D状况,胎儿生长模式和不良怀孕结果在多位预期怀孕队列中的多位预期怀孕队列中
Celeste Beck1, Nathan R Blue2, Robert M Silver2
1Department of Nutritional Sciences, Pennsylvania State University, 110 Chandlee Laboratory, University Park, PA, United States; Department of Research and Evaluation, Heluna Health, City of Industry, CA, United States.
The American journal of clinical nutrition
|November 22, 2024
概括
怀孕早期的母体维生素D与胎儿的线性生长有关. 第一季度维生素D水平较低会增加早产风险,但第二季度维生素D水平没有任何关联.
科学领域:
- 产科和妇科 产科和妇科
- 孕产妇和胎儿医学 孕产妇和胎儿医学
- 营养科学 营养科学
背景情况:
- 关于母亲在整个怀孕期间的维生素D状况及其对胎儿发育的影响的研究有限.
- 维生素D对胎儿生长和怀孕结果的影响的关键妊娠窗口仍然不清楚.
研究的目的:
- 研究母亲在第一和第二个三个月的维生素D水平与胎儿生长模式之间的关联.
- 检查怀孕早期维生素D水平与怀孕结果之间的关系,包括早产和对于妊娠年龄来说小 (SGA).
主要方法:
- 一项前性队列研究的二次分析,该研究涉及美国351名无孕孕妇.
- 血清25-基维生素D (25(OH) D) 在妊娠6-13周和16-21周测量.
- 通过超声波和新生儿人类学评估胎儿生长;计算了早产和SGA风险.
主要成果:
- 第一个三个月25的OH) D与胎儿长度对年龄z-score积极相关 (每10nmol/L的增加与0.05的z-score增加相关).
- 第一个三个月25±OH) D<40nmol/L的参与者与≥80nmol/L的参与者相比,早产风险高4.35倍.
- 没有发现第二季度25(OH) D与胎儿生长或怀孕结果之间有显著的关联.
结论:
- 第一季度母亲的维生素D状况对于胎儿的线性生长至关重要.
- 第一季度维生素D水平较低 (<40nmol/L) 与早产风险增加有关.
- 怀孕第二季度的维生素D状况似乎没有影响胎儿生长或怀孕结果.
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