大脑结构连接拓学预测双相情感障碍青少年的药物反应:一项随机临床试验
1College of Medical Informatics, Chongqing Medical University, Chongqing 400016, China; Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati College of Medicine, Cincinnati 45219, OH, USA; Key Laboratory of Major Brain Disease and Aging Research(Ministry of Education), Chongqing Medical University, Chongqing 400016, China.
Journal of affective disorders
|November 22, 2024
概括
大脑连接拓学预测双相情感障碍在年轻人中的药物反应. 一周内大脑网络的早期变化准确地预测了治疗成功,有助于个性化治疗.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 医疗成像医学成像
- 人工智能的人工智能
背景情况:
- 患有双相情感障碍 (BD) 的年轻人对药物治疗的反应是高度可变和难以预测的.
- 目前的预测方法依赖于临床/人口因素,这些因素是不够的.
- 神经成像生物标志物显示出希望,但大脑连接组拓学的预测价值还未得到充分研究.
研究的目的:
- 调查大脑结构连接学拓学的预测价值,用于青少年患有BD的药物反应.
- 评估基线和早期 (1周) 连接组变化是否可以预测治疗结果.
- 探索深度学习模型开发基于神经成像的生物标志物的潜力.
主要方法:
- 121名BD-I的青少年,以前没有接受过治疗,被随机分配给六周的quetiapine或.
- 结构性MRI扫描是在基线和药物开始后1周获得的.
- 通过拓指标分析大脑结构连接体,将其输入深度学习预测模型.
主要成果:
- 基线和一周的拓指标都预测了治疗反应,准确度为73.8%-86.8%.
- 综合纵向模型实现了最高的预测准确性 (91.3%).
- 预测模型显示奎提亚平和之间的可转移性较差,不同的区域模式推动了预测.
结论:
- 大脑的结构连接拓,无论是在基线和急性变化后,都能准确地预测青年的BD药物反应.
- 独特的大脑区域影响了对奎提阿平与的预测,暗示了药物特定的拓模式.
- 这些发现为神经成像生物标志物提供了初步证据,以指导青少年个性化BD治疗.
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