儿童暴露于非持久性内分泌干扰剂,葡萄糖皮质类固醇和注意力功能:基于参数g-formula的横截面研究
Lorenzo Fabbri1, Oliver Robinson2, Xavier Basagaña1
1ISGlobal, Barcelona, Spain; Universitat Pompeu Fabra, Barcelona, Spain; Spanish Consortium for Research and Public Health (CIBERESP), Instituto de Salud Carlos III, Madrid, Spain.
Environmental research
|November 22, 2024
概括
童年暴露于内分泌干扰化学物质 (EDC),如 parabens 和 phthalates 与注意力不集中的增加有关. 这些EDC还可能破坏下丘脑-垂体-上腺皮层 (HPA) 轴,影响压力激素水平.
科学领域:
- 环境健康 环境健康
- 神经发育毒理学 神经发育毒理学
- 内分泌学 在内分泌学.
背景情况:
- 人们怀疑内分泌干扰化学物质 (EDC) 会影响下丘脑-垂体-上皮层 (HPA) 轴,这对大脑发育至关重要.
- 儿童暴露于特定的EDC,包括有机类农药,和酸盐,需要调查对HPA轴功能和注意力的影响.
研究的目的:
- 评估儿童暴露于EDCs (有机酸盐农药,,酸盐代谢物) 和尿路葡萄皮质类固醇之间的关联.
- 评估EDC暴露和不注意之间的关系,用击中反应时间标准误差 (HRT-SE) 来衡量.
- 探索这些关联中的潜在基于性别的差异.
主要方法:
- 利用了来自人类早期生命暴露组 (HELIX) 队列 (2013-2016) 的数据.
- 采用参数g公式来估计EDC水平与HPA轴标记和注意力不集中之间的关联.
- 根据性别研究的潜在效果修改.
主要成果:
- 对甲基和酸盐代谢物 (oxo-MiNP,oh-MiNP,MEHP) 的暴露增加与注意力降低 (更高的HRT-SE) 有关.
- 几种EDC显示出与皮质素,皮质醇和皮质的尿液水平的积极关联.
- 葡萄糖皮质类固醇水平升高与注意力不集中没有直接联系,但观察到基于性别的效果修改.
结论:
- 研究结果表明,各种EDC可能会对儿童的注意力产生负面影响.
- 有证据表明EDCs可能会干扰HPA轴恒温.
- 需要进一步的研究来了解EDC暴露对神经发育的机制和性别特异性影响.
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