慢性疼痛引起的大脑的功能和结构变化:多模式元分析
Xinglin Zeng1, Yinghao Sun2, Zhao Zhiying3
1Centre for Cognitive and Brain Sciences, University of Macau, 999078, Macao; Faculty of Health Sciences, University of Macau, 999078, Macao.
The journal of pain
|November 22, 2024
概括
慢性疼痛涉及大脑变化,包括岛屿皮层的结构和功能改变. 这种多模式的元分析证实了慢性疼痛患者的一致的神经支.
科学领域:
- 神经科学是一个神经科学.
- 放射学 放射学是一门学科.
- 医疗成像医学成像
背景情况:
- 慢性疼痛是一种广泛的疾病,与严重的大脑变化有关.
- 现有的神经成像研究显示了这种变异性,因此需要采用全面的多模式方法.
研究的目的:
- 通过结构性MRI,静止状态功能连接和疼痛处理期间的功能性MRI进行慢性疼痛中大脑变化的多模式元分析.
- 为了确定与慢性疼痛相关的一致的结构和功能性大脑变化.
主要方法:
- 在PubMed,Embase,Medline和Web of Science的系统文献搜索到2022年5月.
- 使用基于种子的d映射进行结构,功能连接和疼痛处理数据的Voxel-wise元分析.
- 结合分析以确定跨模式的重叠变化.
主要成果:
- 慢性疼痛患者在岛内皮质中表现出结构和功能变化 (灰质减少,连接性改变,激活增加).
- 在疼痛处理与预期方面观察到明显的岛屿皮层激活模式.
- 上回旋和上额回旋显示了交叉模式的变化.
结论:
- 这种多模式的元分析证实了慢性疼痛中持续存在的结构性和功能性大脑变化.
- 这些发现突显了慢性疼痛大脑结构和功能变化之间的复杂相互作用.
- 这项研究促进了对慢性疼痛神经支的理解.
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