蒙特卢卡斯特在患有喘的儿科患者开始治疗后的神经精神病诊断
Tapio Paljarvi1, Julian T Forton2,3, Courtney Thompson4
1Niuvanniemi Hospital, Kuopio, Finland tapio.paljarvi@niuva.fi.
Thorax
|November 22, 2024
概括
蒙特卢卡斯特作为儿童和青少年 (CYP) 喘治疗的补充剂与神经精神病诊断的增加有关. 这包括睡眠,焦虑和情绪障碍,突出了这个年龄组的潜在风险.
科学领域:
- 儿科肺病学 儿科肺病学
- 儿童和青少年精神病学 儿童和青少年精神病学
- 药物监督 药物监督 药物监督
背景情况:
- 关于蒙特卢卡斯特对患有喘的儿童和青少年 (CYP) 的不良影响的证据是不确定的.
- 蒙特卢卡斯特经常被用作吸入性皮质类固醇 (ICS) 的辅助疗法.
研究的目的:
- 为了调查在喘时的CYP中蒙特卢卡斯特启动后的一年神经精神病诊断的发生率.
- 评估蒙特卢卡斯特使用与儿科喘患者神经心理结局之间的关联.
主要方法:
- 一项使用美国电子健康记录 (2015-2019) 的倾向分数匹配队列研究.
- 使用ICD-10-CM代码识别的神经精神病诊断.
- 计算的风险比率 (RRs),绝对风险增加 (ARI) 和伤害所需数量 (NNH).
主要成果:
- 蒙特卢卡斯特的使用与任何神经精神病结局的发病率更高有关 (RR 1.32).
- 睡眠障碍的过度风险最高 (RR 1.63),其次是焦虑和情绪障碍 (RR 1.16).
- 对于任何神经精神病的结果,需要伤害的1年人数 (NNH) 是58名患者.
结论:
- 在ICS上,CYP与喘的辅助蒙特卢卡斯特治疗与神经精神病结局的增加有关.
- 研究结果表明,蒙特卢卡斯特与儿科喘患者的不良神经精神事件之间存在潜在的关联.
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