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患有帕金森病的患者在深度大脑刺激手术后出现妄的危险因素

Enes Ozluk¹, Gulsah Ozturk²

¹Department of Radiology, Basaksehir Cam and Sakura City Hospital, Istanbul, Turkey.

Acta neurochirurgica

|November 22, 2024

概括

晚年和更长的帕金森病持续时间增加了在接受深度大脑刺激 (DBS) 的患者中术后妄想症的风险. 识别高风险个体对于及时干预和改善结果至关重要.

科学领域:

神经外科神经外科
神经学神经学
老年病的医生老年病的医生

背景情况:

手术后妄 (POD) 是神经外科手术后的一个重大问题,可能导致不良的认知结果和延长住院时间.
深度大脑刺激 (DBS) 是帕金森病 (PD) 的常见治疗方法,但该患者群体中POD的风险需要进一步调查.

研究的目的:

确定和评估与经过深度大脑刺激 (DBS) 的帕金森病 (PD) 患者的手术后妄想症 (POD) 发展相关的独立风险因素.

主要方法:

在2016-2023年期间接受双边DBS (准GPi或STN) 的83名异质PD患者的回顾性审查.
患者使用重症监护室 (CAM-ICU) 混评估方法评估 Delirium.
使用多变量逻辑回归和ROC曲线分析来确定POD的独立风险因素,比较人口统计学,疾病特异性和手术变量.

主要成果:

6% (5/83) 的患者患有POD.
确定的重大风险因素包括年龄较大 (>68岁),疾病持续时间较长,手术前大脑缩和手术后危险胀.
疾病持续时间 (≥11年) 是一个强有力的预测因素 (OR: 58.4),年龄 (OR: 1.243) 和疾病持续时间 (OR: 22.52) 被证实为POD的独立风险因素.

结论:

年龄较大和疾病持续时间较长是PD患者接受DBS的POD的重要独立风险因素.
早期识别高风险患者对于主动管理策略至关重要,以减轻POD发生率及其后果.

关键词:

缩性缩症缩性缩症深度大脑刺激是什么?疯狂的 Delirium 是一个很好的方法.内部的白球 (Globus pallidus interna) 已经被发现了.帕金森病是帕金森氏症的一种疾病.亚体的细胞核.

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