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相关概念视频

Cerebral Hemispheres01:05

Cerebral Hemispheres

299
The human brain, a complex organ, is functionally divided into two cerebral hemispheres—left and right. These hemispheres are interconnected by a structure of paramount importance, the corpus callosum. This substantial bundle of neural fibers is not just a bridge between the hemispheres but a crucial element for the brain's comprehensive functioning. It enables efficient communication between the two hemispheres, allowing each side of the brain to control and receive sensory and motor...
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Cerebrum: Anatomical Overview II01:11

Cerebrum: Anatomical Overview II

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Each cerebral hemisphere can be divided into three main regions. The outermost region, the cerebral cortex, is a thin layer (2 to 4 millimeters thick) made up of gray matter, consisting of neuron cell bodies, dendrites, glial cells, and blood vessels. The middle region, or white matter, is primarily composed of myelinated nerve fibers organized into three types of large tracts: association fibers, commissures, and projection fibers. Association fibers connect different areas within the same...
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Cerebrum: Anatomical Overview I01:26

Cerebrum: Anatomical Overview I

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The main and largest component of the human brain is the cerebrum. The cerebrum consists of two main parts: the cerebral cortex, an outer layer with wrinkles or folds known as gyri and shallow grooves called sulci, and a deeper region beneath it. The cerebrum divides into two distinct hemispheres and contains five different lobes: the frontal, parietal, temporal, occipital, and insula. The central sulcus separates the frontal and parietal lobes and two functionally important gyri — the...
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Somatosensation01:33

Somatosensation

36.4K
The somatosensory system relays sensory information from the skin, mucous membranes, limbs, and joints. Somatosensation is more familiarly known as the sense of touch. A typical somatosensory pathway includes three types of long neurons: primary, secondary, and tertiary. Primary neurons have cell bodies located near the spinal cord in groups of neurons called dorsal root ganglia. The sensory neurons of ganglia innervate designated areas of skin called dermatomes.
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Sutures of the Skull01:22

Sutures of the Skull

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The human skull is composed of several bones that come together to protect the brain and support the structures of the face. The junctions where these bones meet are called sutures.
Sutures are immobile joints between adjacent bones of the skull. The narrow gap between the bones is filled with dense, fibrous connective tissue that unites the bones. The long sutures located between the skull bones are not straight but instead follow irregular, tightly twisting paths. These twisting lines tightly...
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相关实验视频

Updated: Jun 6, 2025

Symmetric Bihemispheric Postmortem Brain Cutting to Study Healthy and Pathological Brain Conditions in Humans
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人类皮质中的微观结构不对称.

Bin Wan1,2,3,4, Amin Saberi5,6,7, Casey Paquola6

  • 1Otto Hahn Research Group Cognitive Neurogenetics, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany. binwan@cbs.mpg.de.

Nature communications
|November 23, 2024
PubMed
概括
此摘要是机器生成的。

人类大脑皮层的微观结构不对称性显示了特定层的模式,根据年龄和性别而异. 这种不对称性是遗传的,与功能和行为差异有关,包括语言和心理健康.

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How to Measure Cortical Folding from MR Images: a Step-by-Step Tutorial to Compute Local Gyrification Index
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High-resolution Structural Magnetic Resonance Imaging of the Human Subcortex In Vivo and Postmortem
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相关实验视频

Last Updated: Jun 6, 2025

Symmetric Bihemispheric Postmortem Brain Cutting to Study Healthy and Pathological Brain Conditions in Humans
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How to Measure Cortical Folding from MR Images: a Step-by-Step Tutorial to Compute Local Gyrification Index
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科学领域:

  • 神经科学是一个神经科学.
  • 人类大脑解剖学 人类大脑解剖学
  • 神经成像是一种神经成像.

背景情况:

  • 人类大脑皮层表现出半球不对称性,但底层的微观结构基础尚未完全理解.
  • 了解微观结构不对称对于理解大脑功能和个体差异至关重要.

研究的目的:

  • 为了研究人类大脑皮层层特定的微观结构不对称性.
  • 探索皮质微结构不对称性的遗传性,发育影响 (年龄,性别) 和功能/行为相关性.

主要方法:

  • 使用死后脑组织分析层特异的微结构不对称性.
  • 使用人类结合体项目 (HCP) T1w/T2w数据进行体内成像 (N=1101).
  • 通过体内磁化转移 (N=286) 和定量T1 (N=50) 测量进行验证.

主要成果:

  • 确定了特定层的前后不对称模式,前部区域向左,后部区域向右不对称.
  • 在体内不对称的模式,特别是在III层,与死后发现有很大的相似性.
  • 发现微结构不对称性是遗传的,受年龄和性别的影响,与功能不对称性相关.
  • 观察到语言,心理健康标志物和微观结构不对称轴之间的差异关联.

结论:

  • 这项研究揭示了人类大脑皮层在不同层次的显著微观结构不对称性.
  • 皮层微结构不对称性是遗传的,取决于性别和年龄,并且具有功能相关性.
  • 这些发现提供了对大脑功能和行为分歧的发展基础的见解.