人类皮质中的微观结构不对称
Bin Wan1,2,3,4, Amin Saberi5,6,7, Casey Paquola6
1Otto Hahn Research Group Cognitive Neurogenetics, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany. binwan@cbs.mpg.de.
Nature communications
|November 23, 2024
概括
人类大脑皮层的微观结构不对称性显示了特定层的模式,根据年龄和性别而异. 这种不对称性是遗传的,与功能和行为差异有关,包括语言和心理健康.
科学领域:
- 神经科学是一个神经科学.
- 人类大脑解剖学 人类大脑解剖学
- 神经成像是一种神经成像.
背景情况:
- 人类大脑皮层表现出半球不对称性,但底层的微观结构基础尚未完全理解.
- 了解微观结构不对称对于理解大脑功能和个体差异至关重要.
研究的目的:
- 为了研究人类大脑皮层层特定的微观结构不对称性.
- 探索皮质微结构不对称性的遗传性,发育影响 (年龄,性别) 和功能/行为相关性.
主要方法:
- 使用死后脑组织分析层特异的微结构不对称性.
- 使用人类结合体项目 (HCP) T1w/T2w数据进行体内成像 (N=1101).
- 通过体内磁化转移 (N=286) 和定量T1 (N=50) 测量进行验证.
主要成果:
- 确定了特定层的前后不对称模式,前部区域向左,后部区域向右不对称.
- 在体内不对称的模式,特别是在III层,与死后发现有很大的相似性.
- 发现微结构不对称性是遗传的,受年龄和性别的影响,与功能不对称性相关.
- 观察到语言,心理健康标志物和微观结构不对称轴之间的差异关联.
结论:
- 这项研究揭示了人类大脑皮层在不同层次的显著微观结构不对称性.
- 皮层微结构不对称性是遗传的,取决于性别和年龄,并且具有功能相关性.
- 这些发现提供了对大脑功能和行为分歧的发展基础的见解.
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