多基因评分分析晚年抑郁症抗抑郁药反应,来自IRL-GRey研究的结果
Samar S M Elsheikh1, Victoria S Marshe2, Xiaoyu Men1,3
1Campbell Family Mental Health Research Institute, Center for Addiction and Mental Health, Toronto, ON, Canada.
The pharmacogenomics journal
|November 23, 2024
概括
对注意力缺陷多动症 (ADHD) 和双相情感障碍的多基因风险评分没有预测晚年抑郁症的症状缓解. 关于ADHD多基因风险评分和抗抑郁药反应的先前研究结果在老年人中没有复制.
科学领域:
- 精神病学是一个精神病学.
- 遗传学 是一个遗传学.
- 老年学是一门学科.
背景情况:
- 晚年抑郁症 (LLD) 常常伴有并发症,使抗抑郁药物治疗复杂化.
- 以前的研究表明,治疗耐药性抑郁症 (TRD),多基因风险评分 (PRS) 对于多动症和精神分裂症和双相情感障碍的抗抑郁药反应之间存在联系.
研究的目的:
- 在LLD样本中验证以前关于PRS和抗抑郁药反应之间的关联的发现.
- 检查ADHD,双相情感障碍和其他特征与抑郁症老年人的症状缓解和改善之间的关系.
主要方法:
- 对60岁以上的成年人IRL-GRey样本 (N=342) 进行分析,这些成年人患有接受venlafaxine治疗的大型抑郁症.
- 针对ADHD,抑郁症,精神分裂症,双相情感障碍,神经病,一般智力和抗抑郁药反应的PRS的构建.
- 后勤回归以测试PRS和venlafaxine症状缓解/改善之间的关联,控制共变量.
主要成果:
- 在ADHD的症状缓解和PRS (OR=1.36) 和双相情感障碍的PRS (OR=0.75) 之间发现了名义关联.
- 在一般智力百分比症状改善和PRS之间观察到名义关联 (β=6.81).
- 这些关联没有经历多次测试校正,而ADHD PRS关联的方向与预期相反.
结论:
- 以前的发现将ADHD PRS与抗抑郁药反应联系起来,在老年患有LLD的成年人中没有复制.
- 精神疾病的遗传风险因素可能不会在不同年龄组中以相同的方式影响抗抑郁药治疗结果.
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