异步的丰度波动可以驱动巨大的基因型频率波动
Joao A Ascensao1,2, Kristen Lok1,3, Oskar Hallatschek4,5,6
1Department of Bioengineering, University of California Berkeley, Berkeley, CA, USA.
Nature ecology & evolution
|November 23, 2024
概括
当不同的基因型异步波动时,大量的人口波动可能会导致显著的基因型频率变化. 这种异步波动,称为脱噪声,影响进化超出了遗传漂移.
科学领域:
- 生态生态学 生态生态学
- 进化生物学 进化生物学
- 人口动态 人口动态
背景情况:
- 随机人口丰度波动是常见的,并影响人口动态.
- 富足的波动与泰勒定律指数的两个通常不被认为强烈影响进化.
研究的目的:
- 调查基因型之间的异步丰度波动是否会导致显著的基因型频率波动.
- 开发一个模型,解释这些波动背后的机制及其进化影响.
主要方法:
- 用混合大肠杆菌菌株进行连续稀释实验.
- 开发一个有效的人口和基因型频率波动模型.
- 对Saccharomyces cerevisiae种群进行分离噪声的分析.
主要成果:
- 异步的丰度波动导致基因型频率波动超过了从遗传漂移的预期.
- 一个模型表明,基因型之间的后代数相关性脱驱动了这些大的频率波动.
- 混乱的动态可能是观察到的过度频率波动的基础.
结论:
- 由异步波动引起的脱噪声,独立于遗传漂移,显著影响进化结果.
- 这种现象可能在各种生物种群中普遍存在,因为它具有通用性.
相关概念视频
Mutation, Gene Flow, and Genetic Drift
58.1K
In a population that is not at Hardy-Weinberg equilibrium, the frequency of alleles changes over time. Therefore, any deviations from the five conditions of Hardy-Weinberg equilibrium can alter the genetic variation of a given population. Conditions that change the genetic variability of a population include mutations, natural selection, non-random mating, gene flow, and genetic drift (small population size).
58.1K
Genetic Drift
39.5K
Natural selection—probably the most well-known evolutionary mechanism—increases the prevalence of traits that enhance survival and reproduction. However, evolution does not merely propagate favorable traits, nor does it always benefit populations.
39.5K
Gene Flow
34.8K
Gene flow is the transfer of genes among populations, resulting from either the dispersal of gametes or from the migration of individuals.
34.8K
Hardy-Weinberg Principle
71.8K
Diploid organisms have two alleles of each gene, one from each parent, in their somatic cells. Therefore, each individual contributes two alleles to the gene pool of the population. The gene pool of a population is the sum of every allele of all genes within that population and has some degree of variation. Genetic variation is typically expressed as a relative frequency, which is the percentage of the total population that has a given allele, genotype or phenotype.
71.8K
What is Population Genetics?
57.6K
A population is composed of members of the same species that simultaneously live and interact in the same area. When individuals in a population breed, they pass down their genes to their offspring. Many of these genes are polymorphic, meaning that they occur in multiple variants. Such variations of a gene are referred to as alleles. The collective set of all the alleles within a population is known as the gene pool.
57.6K
Genome Size and the Evolution of New Genes
7.9K
While every living organism has a genome of some kind (be it RNA, or DNA), there is considerable variation in the sizes of these blueprints. One major factor that impacts genome size is whether the organism is prokaryotic or eukaryotic. In prokaryotes, the genome contains little to no non-coding sequence, such that genes are tightly clustered in groups or operons sequentially along the chromosome. Conversely, the genes in eukaryotes are punctuated by long stretches of non-coding sequence.
7.9K


