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关闭模块化驱动改变了前额叶皮层动态和连接性的驱动

Ryan Zahacy¹, Yonglie Ma², Ian R Winship^1,2

¹Neuroscience and Mental Health Institute, University of Alberta, Edmonton, AB, Canada.

Communications biology

|November 23, 2024

概括

关闭层 (大脑区域) 影响皮质活动和大规模的大脑网络. 调节关节活动会改变前额叶皮质功能和感官反应,突出其在神经通信中的作用.

科学领域:

神经科学是一个神经科学.
计算神经科学是一种神经科学.
系统神经科学系统神经科学

背景情况:

关闭层是一个鲜为人知的下皮层结构.
它在调节皮层活动和大规模大脑网络方面的确切作用尚不清楚.

研究的目的:

研究关闭层对自发和感官唤起的皮质网络活动的影响.
确定关闭层调制如何影响前额叶皮质活动和远程功能连接.

主要方法:

在麻醉小鼠中进行中尺度成像.
使用Gi和GqDREADDs进行化学遗传操纵,以改变闭塞活动.

主要成果:

关节活动的减少增强了前额叶皮质活动;激活减少了它.
闭层调制改变了大规模的功能性大脑网络和远程皮质连接.
闭层抑制增加了局部额叶皮层的合,但减少了长距离的相关性,同时增强了视觉皮层的感官反应.

结论:

关闭层在协调皮层区域内的神经通信方面发挥着重要作用.
幽室活动调节前额叶皮层功能,大规模网络动态和感官处理.
闭膜是调节大规模皮层动态的一个关键节点.

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