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miRTarBase 2025:对经过实验验证的微RNA-目标相互作用的集合进行更新
Shidong Cui1,2, Sicong Yu1,2, Hsi-Yuan Huang1,2
1School of Medicine, The Chinese University of Hong Kong, Shenzhen, Guangdong 518172, P.R. China.
Nucleic acids research
|November 23, 2024
概括
现在miRTarBase数据库包含超过380万个经验证的microRNA-target相互作用,包括药物耐药性和生物标志物发现中的作用. 这个扩展提供了对基因调节和治疗策略的更深入的见解.
科学领域:
- 分子生物学分子生物学
- 生物信息学是一种生物信息学.
- 基因组学就是基因组学.
背景情况:
- 微RNA (miRNA) 是小型非编码RNA,在转录后调节基因表达.
- 经过实验验证的miRNA-目标相互作用 (MTIs) 对于理解细胞过程和疾病至关重要.
- 现有的数据库需要大幅扩展,以涵盖越来越多的MTI研究.
研究的目的:
- 更新和扩展miRTarBase数据库,以一个全面的实验验证的MTIs集合.
- 将miRNA与治疗剂的相互作用和氧化miRNA序列的新数据纳入.
- 加强miRTarBase在分子瘤学,药物开发和生物标志物发现方面的研究的实用性.
主要方法:
- 从科学文献中收集并整合经过实验验证的MTIs.
- 包括关于miRNA与药物相互作用,耐药性和毒性的数据.
- 应用先进的自然语言处理 (NLP) 模型,包括快速工程的LLAMA3,以有效地识别MTI和miRNA疾病关联.
- 添加有关氧化miRNA序列及其调节影响的信息.
主要成果:
- 更新后的 miRTarBase 现在包含了 13,690 篇文章中的 3,817,550 多个验证的 MTIs,与之前的版本相比大幅增加.
- 新的条目详细介绍了miRNA在耐药性,治疗策略以及作为毒性和临床治疗的生物标志物的作用.
- 扩展的miRNA-mRNA和miRNA-miRNA网络有助于识别关键的调节基因和共同调节的miRNA.
- 整合LLAMA3模型使得有效的MTI和miRNA-疾病关联发现没有广泛的训练数据.
结论:
- 扩展的miRTarBase作为分子瘤学,药物开发和精密医学研究人员不可或缺的资源.
- 该数据库提供了对miRNA功能,监管网络及其对治疗干预和疾病管理的影响的关键见解.
- 增强的数据集成和重新设计的用户界面提高了可访问性,并促进了对miRNA生物学的更深入的探索.
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