PBPK建模用于评估美罗和酸之间的药物相互作用

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Hongrui Liu1, Yiqun Yu1, Yulin Qin1

  • 1Department of Pharmacy, Minhang Hospital, Fudan University, Shanghai, China.

British journal of clinical pharmacology
|November 23, 2024
PubMed
概括

使用PBPK模型研究了美罗 (MEPM) 和酸 (VPA) 药物相互作用 (DDI). 模拟表明MEPM可能会影响VPA水平,推特定的剂量间隔或给药途径.

关键词:
乙烯基酸化酶 (APEH) 的使用药物药物相互作用 (DDI)梅罗胺 (MEPM) 是一种基于生理学的药理动力学 (PBPK) 建模.多态的多态化.瓦尔酸 (VPA) 是一种

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