高血红蛋白与红细胞分布宽度比率减少了心脏起器植入患者的不良事件
Liyou Lian1, Rujie Zheng2, Kaijing Wang3
1Department of Internal Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
BMC cardiovascular disorders
|November 23, 2024
概括
高血红蛋白与红细胞分布宽度 (Hb/RDW) 的比率预测心脏病发作患者的重大心血管事件 (MCE) 较少. 这个比率是一个比单独的血红蛋白或RDW更有效的预测指标.
科学领域:
- 心脏病学 心脏病学
- 血液学 血液学 血液学
- 生物标志物 生物标志物
背景情况:
- 在心脏起器植入 (PMI) 后,血红蛋白与红细胞分布宽度 (Hb/RDW) 比率的预后值尚未得到充分确立.
- 主要心血管事件 (MCE) 对带有起器的患者构成重大风险.
研究的目的:
- 调查Hb/RDW比率与中国永久PMI患者中MCE风险之间的潜在关联.
- 为了确定Hb/RDW比率是否是MCE的优越预测因素,而不是血红蛋白 (Hb) 或红细胞分布宽度 (RDW).
主要方法:
- 分析了595名患有永久性PMI的患者队列.
- 根据ROC曲线分析,患者被分为高Hb/RDW (≥9.1g/L/%) 和低Hb/RDW (<9.1g/L/%) 的两组.
- 主要终点是MCE的组合,包括心力衰竭,心肌梗塞,中风和全因死亡的住院治疗,使用Cox模型,倾向得分调整和反向概率加权来分析.
主要成果:
- 在平均2年的随访期间,95人 (16%) 发生了MCE.
- 高Hb/RDW组的患者与低Hb/RDW组相比,MCE的风险显著降低 (调整HR:0.456;95%CI:0.376-0.848).
- 在倾向得分调整 (HR:0.592) 和反向概率加权 (HR:0.444) 分析中观察到一致的结果.
结论:
- 较高的Hb/RDW比值与PMI患者中复合MCE风险降低有关.
- 在这种患者群体中,Hb/RDW比率是MCE的更强有力的预测因素,而不是单独Hb或RDW.
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