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抵抗训练改善了多发性硬化症妇女的功能能力:一个随机对照试验

Nasrin Niazi Nezhad¹, Abdolhossein Parnow², Kianoosh Khamoushian³

¹Bio-Sciences Department, Physical Education and Sports Sciences Faculty, Razi University, University Street, Kermanshah, Iran.

|November 23, 2024

概括

抵抗运动训练 (RT) 在患有多发性硬化症 (MS) 的女性中显著改善了肌肉力量,功能能力,生活质量,减少了疲劳. 氧化应激标志物没有受到培训计划的影响.

科学领域:

神经学神经学
运动生理学运动生理学
免疫学免疫学免疫学

背景情况:

多发性硬化症 (MS) 是一种慢性自身免疫性疾病,影响中枢神经系统.
多发性硬化会导致渐进的残疾,影响肌肉力量,功能能力和生活质量.
氧化应激对MS的发病和进展起着重要作用.

研究的目的:

评估一个为期12周的抵抗运动训练 (RT) 计划对氧化状态,肌肉力量,功能能力,生活质量 (QoL) 和复发性复发性MS的女性疲劳的影响.
在MS患者和健康对照中比较RT与不运动的影响.

主要方法:

一项随机对照试验涉及25名患有多发性硬化症的女性 (年龄在18-45岁,EDSS ≤4岁),分为具有RT的MS和没有RT的MS组.
RT组接受了12周的培训,每周3次,每周60-80%.
评估结果包括氧化应激标志物 (MDA,SOD,GPx),肌肉强度 (5-RM),功能能力 (T25FWT,2MWT,5STS,MSWS-12),手的灵巧 (9-HPT),QOL (31-MusiQoL) 和疲劳 (FSMC).

主要成果:

与没有RT的MS组相比,RT显著改善了肌肉力量 (腿伸展,腿曲,长椅压力) 和功能能力 (T25FWT,2MWT,5STS,MSWS-12) .
观察到左手灵巧度,疲劳和 QoL 的改善.
在氧化应激标志物 (MDA,SOD,GPx) 或右手敏捷度中没有发现统计学意义上的变化.

结论:

12周的抵抗运动训练对MS患者的肌肉力量,功能能力,生活质量和疲劳产生了积极的影响.
在这个人群中,RT并没有显著改变氧化应激标志物.
虽然RT为MS患者提供了明显的好处,但针对氧化应激仍然是未来临床发展的重要领域.

关键词:

疲劳疲劳疲劳疲劳疲劳功能能力功能能力多发性硬化症是多发性硬化症.肌肉的力量肌肉的力量氧化应激标志物氧化应激标志物阻力训练阻力训练阻力训练

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