慢性外源性催产素给药对运动表现和心血管控制在大鼠下性缺氧的作用
Camila Salazar-Ardiles1,2, Carlos Cornejo1, Cristobal Paz1
1Exercise Applied Physiology Laboratory, Centro de Investigación en Fisiología y Medicina de Altura (FIMEDALT), Departamento Biomedico, Facultad de Ciencias de la Salud, Universidad de Antofagasta, Antofagasta, Chile.
在老鼠中长期使用氧化 (OXY) 预防了在高海拔低压性缺氧 (HH) 期间运动性能下降和阴道控制障碍. 这表明OXY可以减轻HH对身体能力的负面影响.
科学领域:
- 运动生理学 运动生理学
- 高度生理学 高度生理学
- 心血管监管 监管心血管系统
背景情况:
- 高海拔的低压-低氧 (HH) 损害了运动表现,并减少了副交感驱动.
- 阴道控制对于保持运动能力至关重要.
- 外源性催产素 (OXY) 在缓解HH诱导的运动障碍方面的作用尚不清楚.
研究的目的:
- 研究长期外源性催产素 (OXY) 给药对暴露于低性缺氧 (HH) 的老鼠运动表现的影响.
主要方法:
- 鼠每天接受OXY或车辆14天.
- 增量运动和巴罗反射测试在常态性常态氧 (NN) 和HH (模拟3,500米) 下进行.
- 测量是在14天的服药期间之前和之后进行的.
主要成果:
- 14天后,OXY组在HH中保持了运动表现,与显著下降的车辆组不同.
- 在OXY组中,保持了HH中的巴罗反射灵敏度和心反应,而在载体组中这些反应受损.
- 低氧呼吸反应在各组之间保持相似.
结论:
- 长时间服用OXY有效地预防了短期高血压期间的运动表现下降.
- 在HH条件下,OXY的使用还能保持管控制机制.
- 这些发现突出了OXY在管理与高度相关的生理压力的潜在治疗作用.
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