在代谢性肝病的尿素和TCA循环中涉及的非侵入性生物标志物
Guiyan Yang1, Yu-Jui Yvonne Wan2
1College of Veterinary Medicine, China Agricultural University, Beijing, 100193, China.
Biomarker research
|November 23, 2024
概括
胆酸 (BA) 和FXR是新陈代谢的关键. 肠道微生物群和尿液/血清中的代谢物可以作为与饮食,衰老和FXR不活性相关的代谢困境的生物标志物.
科学领域:
- 代谢学 代谢学 代谢学
- 微生物组学 微生物组学
- 系统生物学 系统生物学
背景情况:
- 胆酸 (BA) 和它们的受体Farnesoid X受体 (FXR) 是宿主新陈代谢的关键调节者.
- 受肝脏和细菌酶影响的BA合成失调,有助于代谢功能障碍相关的脂肪肝炎 (MASH) 和肝细胞癌 (HCC).
- 肝脏的代谢状态受到肠道微生物群及其代谢物的显著影响,这是由于从肠道流出的大量血液流动.
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