毒素注射与慢性裂的侧面内切除术:随机对照试验的元分析
Ali Bonyad1, Reza Hossein Zadeh2, Setareh Asgari3
1Faculty of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
Langenbeck's archives of surgery
|November 23, 2024
概括
与肉毒毒素注射相比,侧侧内切除术显示裂的愈合率更高. 这一系统性审查强调了慢性裂的传统手术的有效性.
科学领域:
- 结肠直肠手术 结肠直肠手术
- 胃肠病学 胃肠病学
- 最少侵入性手术的方法
背景情况:
- 门裂影响了11%的人口,导致疼痛和出血.
- 传统的手术治疗,侧侧内切除术,有相关的术后并发症.
- 毒素注射是一种侵入性较小的替代方案,报告的副作用较少.
研究的目的:
- 为了比较毒素注射与慢性裂的侧面内切除术的有效性.
- 评估两种治疗方式之间的愈合率和临床结果.
主要方法:
- 随机对照试验的系统审查和元分析.
- 在PubMed,Scopus和谷歌学者中进行文献搜索,截至2023年10月.
- 遵守PRISMA指南;在OSF注册的研究协议.
主要成果:
- 包括18项试验中的1839名患者.
- 与肉毒毒素注射相比,侧侧内切除术显示出明显更高的愈合率 (整体效果 = 0.77;95% CI [0.69-0.83])
- 在研究中观察到高异质性 (I2 = 90.95%).
结论:
- 侧侧内切除术在促进慢性裂愈合方面更有效.
- 传统的手术干预为治疗裂提供了临床优势.
- 需要进一步的长期后续研究来验证这些发现.
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