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在68Ga-PSMA PET/CT中初级评分:与前列腺癌风险组的相关性及其对积极监测的潜在影响

Hatice Uslu¹, Dilruba Şahin², Ebru İbişoğlu¹

¹Clinic of Nuclear Medicine, Istanbul Medeniyet University Göztepe Prof. Dr. Süleyman Yalçın City Hospital, Eğitim Mah. Fahrettin Kerim Gökay Cd., 34722, Kadikoy, Istanbul, Turkey.

Annals of nuclear medicine

|November 23, 2024

概括

主要评分系统有助于识别前列腺癌患者进行主动监测. 将其与SUVmax值相结合,可以提高选择合适候选人的准确性.

科学领域:

核医学就是核医学.
在瘤学瘤学.
放射学放射学是一门学科.

背景情况:

积极监测是低风险前列腺癌的管理策略.
在68Ga-PSMA PET/CT上,PRIMARY评分系统有助于识别显著的前列腺内恶性瘤.
准确的患者选择对于积极监测的成功至关重要.

研究的目的:

评估PRIMARY评分系统在选择适合主动监控候选人的有效性.
评估PRIMARY分数在不同前列腺癌风险组中的分布.
确定PRIMARY评分是否可以补充PI-RADS等现有方法.

主要方法:

对134名经过活检证明的前列腺癌患者进行了回顾性分析,这些患者接受了68Ga-PSMA PET/CT.
收集的数据包括年龄,PSA,ISUP等级,SUVmax,PI-RADS和Primary分数.
患者被分为低风险和中等/高风险组.

主要成果:

在中等/高风险患者中,82.4%的Primary得分为3至5,低风险组为65.3%.
在这两组中,PRIMARY评分4是最常见的,风险组之间的SUVmax差异显著 (p=0.018).
在ROC分析中,PRIMARY评分的AUC为0.727,PI-RADS的AUC为0.662,它们的组合为0.744.

结论:

通过PRIMARY评分系统,可以帮助PI-RADS在选择患者进行主动监测方面发挥作用.
修改PRIMARY评分4以SUVmax截止值可能会提高患者选择的特异性.
进一步完善PRIMARY评分系统可以提高其在前列腺癌管理中的效用.

关键词:

积极监视活动的监视活动.多参数核磁共振成像聚乙烯/聚乙烯/聚乙烯在PSMA上,PSMA可以在PSMA上进行交易.前列腺癌是什么意思前列腺癌是什么意思

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