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相关概念视频

Tumor Immunotherapy01:27

Tumor Immunotherapy

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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The Tumor Microenvironment02:17

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Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
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Receptor Downregulation in MVBs01:15

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Multivesicular bodies (MVBs) are mature endosomes that sort ubiquitinated proteins and then fuse with lysosomes to degrade the sorted proteins. Epidermal growth factor (EGF) and its receptor (EGFR) form a complex that can be internalized through endocytosis, sorted into an MVB, and later degraded.
The EGFR can initiate signaling pathways that  lead to cell proliferation, migration, and differentiation. Overexpression of EGFR  stimulates cells to proliferate. Excessive  EGFR...
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Cytotoxic T Cells-mediated Immune Response01:27

Cytotoxic T Cells-mediated Immune Response

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Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
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Inflammatory Response01:28

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An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
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mTOR Signaling and Cancer Progression03:03

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The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
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相关实验视频

Updated: Jun 6, 2025

Studying the Effects of Tumor-Secreted Paracrine Ligands on Macrophage Activation using Co-Culture with Permeable Membrane Supports
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Studying the Effects of Tumor-Secreted Paracrine Ligands on Macrophage Activation using Co-Culture with Permeable Membrane Supports

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在瘤免疫逃避中的补充调节.

Guijun Liu1, Xuxiao He1, Gaoxiang Zhao2

  • 1Zhejiang Key Laboratory of Pancreatic Disease, The First Affiliated Hospital, Zhejiang Key Laboratory of Frontier Medical Research on Cancer Metabolism, Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310029, China; Institute of Fundamental and Transdisciplinary Research, Zhejiang University, Hangzhou, Zhejiang 310029, China; Zhejiang University Cancer Center, Hangzhou, Zhejiang 310029, China.

Seminars in immunology
|November 23, 2024
PubMed
概括

补体系统有助于免疫反应对病原体和受损细胞. 在瘤中,它可以矛盾地促进免疫逃避和癌症的进展.

关键词:
补充系统的补充系统.免疫细胞是免疫细胞.豁免权是一种豁免权.在MCRP中,MCRP是最常见的.瘤是一个瘤.瘤微环境是一个微环境.

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Evaluation of Tumor-infiltrating Leukocyte Subsets in a Subcutaneous Tumor Model
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Studying the Effects of Tumor-Secreted Paracrine Ligands on Macrophage Activation using Co-Culture with Permeable Membrane Supports
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科学领域:

  • 免疫学 免疫学 免疫学
  • 癌症生物学 癌症生物学

背景情况:

  • 补体系统是天生的和适应性免疫的关键组成部分.
  • 它有助于消除病原体和受损细胞,包括癌细胞.
  • 它的调节与细胞介导免疫结合在一起.

研究的目的:

  • 阐明补充系统在瘤微环境中的双重作用.
  • 了解补充剂如何影响瘤进展和免疫逃避.

主要方法:

  • 对癌症中补充通路的现有文献的审查.
  • 对补体与瘤和免疫细胞相互作用的分析.
  • 研究补充激活依赖和独立的机制.

主要成果:

  • 补体系统在瘤中具有免疫促进和免疫抑制的功能.
  • 它调解了影响瘤细胞的免疫和非免疫功能.
  • 补充途径有助于瘤免疫逃避和进展.

结论:

  • 补体系统在癌症中起着复杂的,取决于背景的作用.
  • 向补充通路可能为癌症治疗提供治疗策略.
  • 需要进一步的研究才能充分理解补充剂对瘤微环境的影响.