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素通过调节线粒体动态和巨细胞两极分化,通过JAK2/STAT3通路改善牙周炎

SiJia Ma¹, Hongbing He¹, Xiaobin Ren¹

¹Department of Periodontology, Kunming Medical University School and Hospital of Stomatology, Kunming 650106, China; Yunnan Key Laboratory of Stomatology, Kunming 650106, China.

International immunopharmacology

|November 23, 2024

概括

素 (LUT) 通过减少骨损失和炎症,有效治疗牙周病 (PD). 它通过改善线粒体功能,促进M2巨细胞两极分化,并抑制JAK2/STAT3通路而起作用.

科学领域:

口腔生物学和病理学
免疫学和炎症免疫学和炎症
线粒体生物学线粒体生物学

背景情况:

牙周病 (PD) 是一种普遍的慢性炎症状况,影响口腔和全身健康.
素 (LUT) 是一种天然存在的黄类化合物,具有抗炎性质,但其在PD中的特定治疗机制需要阐明.

研究的目的:

为了研究素 (LUT) 对牙周病 (PD) 的治疗作用.
确定LUT对线粒体动力学,巨细胞极化以及PD中JAK2/STAT3信号通路的影响.

主要方法:

采用网络药理学,体内 (大鼠PD模型) 和体内 (巨) 实验.
使用微型CT,通过流动细胞计测量进行巨细胞极化,并使用西方斑块进行途径分析来评估气膜骨损失.

主要成果:

LUT显著降低了骨质损失,并促进了M2巨细胞的两极分化 (增加了CD206,Arg1).
通过降低ROS,恢复膜潜力,减少裂变和增强融合,LUT改善了线粒体功能.
LUT 抑制了 JAK2/STAT3 酸化,这表明它具有抗炎机制.

结论:

素 (LUT) 改善牙周炎症和骨质损失.
LUT调节线粒体动力学,增强M2巨细胞两极分化,并抑制JAK2/STAT3通路.
LUT为牙周病提供了一个有前途的多目标治疗候选药物.

关键词:

在JAK2/STAT3信号系统中,可以使用JAK2/STAT3信号.卢特奥林是什么意思?卢特奥林是什么意思?巨细胞的两极分化线粒体动力学的动态牙周病是牙周病的一种疾病.

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The JAK-STAT Signaling Pathway

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Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as SH2...