环境暴露和生育能力:挪威母亲,父亲和儿童队列研究
Thea Grindstad1, Siri E Håberg2, Olga Basso3
1Centre for Fertility and Health, Norwegian Institute of Public Health, Oslo, Norway.
International journal of hygiene and environmental health
|November 23, 2024
概括
农药和摄影化学品等环境暴露可能会降低女性怀孕的能力. 对消毒剂的暴露显示,男女生育能力略有增加. 需要进一步研究环境对生育能力的影响.
科学领域:
- 环境健康 环境健康
- 生殖流行病学 生殖流行病学
- 毒理学 毒理学 毒理学
背景情况:
- 环境暴露越来越被认为是影响人类生育能力的潜在因素.
- 了解这些关联对于制定有针对性的公共卫生建议和干预措施至关重要.
- 以前的研究表明,某些暴露与降低生育率之间存在联系,但仍需要全面的数据.
研究的目的:
- 为了研究自我报告的环境暴露和大量挪威队列中的生育能力之间的关联.
- 确定可能对怀孕时间产生负面或积极影响的特定环境因素.
- 为与生殖健康相关的环境暴露指南提供基于证据的信息.
主要方法:
- 利用了挪威母亲,父亲和儿童队列研究 (MoBa) 中64,942名女性和53,219名男性的数据.
- 评估了女性对17种环境因素和男性对19种环境因素的自我报告暴露,包括农药,重金属和辐射.
- 采用日志双项回归来估计生育率 (FR),比较暴露和未暴露个体之间的受孕概率.
主要成果:
- 大约50%的女性和75%的男性报告至少一次环境暴露.
- 暴露于任何农药 (FR 0.94) 和频繁的摄影化学物质暴露 (FR 0.84) 在女性中与降低生育能力有关.
- 对暴露于消毒剂的女性 (FR 1.02) 和男性 (FR 1.03) 均观察到生育能力略有增加.
结论:
- 农药和摄影化学物质的暴露可能会对女性的生育能力产生负面影响.
- 消毒剂暴露显示出与男女生育能力的潜在积极关联.
- 这些发现强调了在生殖健康评估中考虑特定环境暴露的重要性.
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