使用可穿戴技术在COPD自由生活的门诊患者中不断描述恶化病理生理学:一项前性观察队列研究
Felix-Antoine Coutu1, Olivia C Iorio2, Seyedfakhreddin Nabavi2
1Respiratory Epidemiology and Clinical Research Unit, Centre for Outcomes Research and Evaluation, Research Institute of the McGill University Health Centre, Montreal, QC, Canada; Department of Medicine, McGill University, Montreal, QC, Canada.
EBioMedicine
|November 23, 2024
概括
这项研究使用可穿戴传感器揭示了COPD恶化期间的生理模式. 这些发现可能会改善远程监测和了解慢性阻塞性肺病 (COPD) 患者的疾病进展.
科学领域:
- 肺部医学 肺部医学
- 生物医学工程 生物医学工程
- 数字健康数字健康
背景情况:
- 目前的COPD恶化 (ECOPD) 标准包括呼吸速率 (RR),心率 (HR) 和氧和 (SpO2).
- 对恶化模式和可靠的生理生物标志物的全面理解仍然难以捉摸.
- 可穿戴技术为COPD患者的持续,现实世界的监测提供了潜力.
研究的目的:
- 使用连续,远程数据收集,以前性地描述COPD恶化期间的生理模式.
- 确定与症状负担和恢复状态相关的潜在生理生物标志物.
- 探索可穿戴传感器在自由生活条件下监测 ECOPD 的实用性.
主要方法:
- 展望观察队列研究 (2023年2月 - 2024年1月) 连续21天收集数据.
- 可穿戴的生物识别腕带和戒指用于持续监测呼吸,心血管,自主,活动和睡眠参数.
- 每日症状负担评估的EXACT-PRO问卷;用于分析的线性混合效应模型.
主要成果:
- 在RR可变性,每日步数和睡眠效率与每日EXACT-PRO得分之间发现了显著的关联.
- 在"康复"的参与者中,夜间HR,运动强度和SpO2都显著.
- 在"持续恶化"的参与者中,HR变化,夜间RR变化,SpO2,睡眠效率和皮肤温度显示出显著的关联.
结论:
- 这项研究通过远程监测提供了COPD恶化的持续,现实世界的特征.
- 识别的生理模式可以提高对恶化的理解,并为远程监测解决方案的开发提供信息.
- 使用可穿戴设备的门诊数据收集显示出对管理COPD恶化有希望.
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