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患有物质使用障碍的青少年及其未受影响的兄弟姐妹的休息状态功能连接

Hakan Kayış¹, Betül Akyel Göven², Zeki Yüncü¹

¹Department of Child Psychiatry, Ege University School of Medicine, Izmir, Turkey.

Psychiatry research. Neuroimaging

|November 23, 2024

概括

患有物质使用障碍 (SUD) 的青少年表现出大脑连接的改变,特别是在默认模式网络 (DMN) 中. 这些连接性变化,包括较低的DMN连接性,在他们的兄弟姐妹中也存在,这表明SUD的家族风险.

科学领域:

神经科学是一个神经科学.
精神病学是一个精神病学.
遗传学是一个遗传学.

背景情况:

药物使用障碍 (SUD) 是一种复杂的疾病,具有遗传和环境影响.
了解SUD的家族风险因素对于早期干预和预防策略至关重要.

研究的目的:

调查与典型发育对照 (TDC) 相比,SUD青少年及其未受影响的兄弟姐妹 (SIB) 的静止状态功能连接 (rsFC) 改变.
为了确定与SUD家族风险相关的神经网络组织变化.

主要方法:

使用了静止状态功能磁共振成像 (rsFC).
基于网络的分析对三组进行:SUD (n=20),SIB (n=20) 和TDC (n=18) 的青少年.

主要成果:

与TDC相比,患有SUD的青少年表现出明显较弱和较强的rsFC,主要是在默认模式网络 (DMN) 内部以及DMN,前端对象网络 (FPN) 和突出网络之间.
在患有SUD的青少年中,观察到视觉网络与其他功能网络之间较低的rsFC.
兄弟姐妹 (SIB) 显示DMN连接性降低和视觉网络连接性改变,反映了SUD组中发现的一些异常,表明家族性倾向.

结论:

在rsFC的共同变化,特别是较低的DMN连接性和较高的DMN-FPN连接性,在SUD和他们的兄弟姐妹的青少年中都观察到.
这些发现表明,这些特定的连接模式可能代表着对SUD的家族性倾向.

关键词:

在Connectomics上,我们提供了连接.末型是一种内类型.功能连接性的功能连接性.使用物质使用物质.

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