相关实验视频

Updated: Jun 6, 2025

Induction and Analysis of Epithelial to Mesenchymal Transition

Induction and Analysis of Epithelial to Mesenchymal Transition

Published on: August 27, 2013

在急性髓性白血病中,NAP1L5通过调节PEG10表达来促进表皮层-介质细胞过渡

Huan Wu¹, Hang Luo², Meng Wang³

¹School of Mental Health, Bengbu Medical University, Bengbu, Anhui 233000, China; Department of Hematology, The First Affiliated Hospital of Bengbu Medical University, Bengbu, Anhui 233000, China.

Leukemia research

|November 23, 2024

概括

在急性髓性白血病 (AML) 中,NAP1L5的表达升高,促进瘤生长和上皮细胞-介质细胞过渡. 针对NAP1L5及其下游因素PEG10可能为AML治疗提供新的治疗策略.

科学领域:

血液学血液学血液学
癌症生物学癌症生物学
分子瘤学分子瘤学

背景情况:

急性髓性白血病 (AML) 是一种危及生命的血液性恶性瘤.
在AML患者中观察到高NAP1L5表达,但其作用尚不清楚.

研究的目的:

研究AML中NAP1L5的致病机制.
探索NAP1L5,瘤生长和上皮层-介质细胞过渡 (EMT) 之间的关系.

主要方法:

在AML中分析NAP1L5表达水平.
研究NAP1L5和PEG10在瘤进展和EMT中的作用.

主要成果:

在AML中,NAP1L5的表达上调,与瘤生长和EMT相关.
PEG10作为NAP1L5的下游调节剂,促进瘤生长和EMT.
失去PEG10可以抵消NAP1L5过度表达的不良影响.

结论:

通过促进瘤生长和EMT,NAP1L5与AML病变发生有关.
NAP1L5及其下游效应器PEG10代表了AML的潜在治疗点.

关键词:

患有急性髓性白血病的人群.皮质介质酶过渡皮质介质过渡 NAP1L5L5L5NAP1L5L5L5NAP1L5L5NAP1L5L5NAP1L5L5NAP1L5L5NAP1L5NAP1L5L5NAP1L5L5NAP1L5NAP1L5L5NAP1L5NAP1L5NAP1L5NAP1L5NAP1L5NAP1L5NAP1L5NAP1L5NAP1L5NAP1L5NAP1L5NAP1L5NAP1L5NAP1L5NAP1L5NAP1L5NAP1L5NAP1L5NAP1L5 在PEG10的基础上,PEG10

更多相关视频

Proliferation and Differentiation of Murine Myeloid Precursor 32D/G-CSF-R Cells

Proliferation and Differentiation of Murine Myeloid Precursor 32D/G-CSF-R Cells

Published on: February 21, 2018

Induction of Mesenchymal-Epithelial Transitions in Sarcoma Cells

Induction of Mesenchymal-Epithelial Transitions in Sarcoma Cells

Published on: April 7, 2017

相关概念视频

Abnormal Proliferation

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...

Metastasis

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...

Role Of Notch Signalling In Intestinal Stem Cell Renewal

Role Of Notch Signalling In Intestinal Stem Cell Renewal

Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...