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基于血清微量营养素对结直肠癌患者的分类:一项探索性调查

Krishnamurthy Hari¹, Rosanna Squitti², Jophi Bosco³

¹Vibrant Sciences LLC, San Carlos, CA, United States of America.

Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)

|November 23, 2024

概括

结肠直肠癌 (CRC) 患者表现出血清微量营养素水平的改变,和铜水平与瘤分期显著相关. 这些发现表明微量营养素在CRC进展中起作用.

科学领域:

在瘤学瘤学.
营养生物化学营养生物化学
癌症研究癌症研究

背景情况:

结肠直肠癌 (CRC) 是一个严重的全球健康问题.
它的发展涉及遗传,营养和炎症因素.

研究的目的:

调查诊断为结直肠癌 (CRC) 的患者的微量营养素状况.
为了比较CRC患者和健康对照人群之间的血清微量营养素水平.

主要方法:

对13名CRC患者和10名健康对照进行了病例控制研究.
分析了29种微量营养素的血清水平,包括维生素,矿物质和氨基酸.

主要成果:

与对照组相比,CRC患者的血清铜和氨酸含量增加,但,,维生素B1,维生素K1和维生素A含量减少.
血清水平准确预测了CRC诊断,并与淋巴结转移 (pN) 相相关.
血清铜水平与CRC的病理性瘤结节转移 (pTNM) 阶段确定有很强的关联.

结论:

血清微量营养素概况与结直肠癌 (CRC) 的进展有关.
变化的微量营养素水平可能是由于瘤需求增加和抗氧化功能变化.
需要对更大的队列进行进一步的纵向研究来证实这些初步发现.

关键词:

结肠直肠癌是一种癌症.半氨酸 (cysteine) 是一种氨酸.微量营养素铜铜是一种.维生素B1 维生素B1 是一种维生素.可以在中找到.的 pTNMM 的时间.

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