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母亲分居压力对青少年小鼠乙醇摄入量和内分泌系统的影响

C A Favoretto¹, N B Bertagna², A Anjos-Santos²

¹Molecular and Behavioral Neuroscience Laboratory, Pharmacology Department, Universidade Federal de São Paulo, São Paulo, Brazil; Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA, USA.

|November 23, 2024

概括

在小鼠的早期生活压力增加了乙醇消费和偏好高度. 内分泌大麻素系统和神经元激活在很大程度上不受这种压力的影响.

科学领域:

神经科学是一个神经科学.
药理学药理学是指药理学的学科.
行为科学行为科学

背景情况:

早期的生活压力是乙醇使用障碍的危险因素.
内分泌大麻素系统 (eCB) 影响压力和乙醇消费.
早期生活压力和乙醇暴露对eCB系统的影响尚不清楚.

研究的目的:

研究母亲分居 (MS) 压力对小鼠青少年乙醇消费的影响.
确定MS如何影响内分泌大麻素系统和奖励相关大脑区域的神经元激活.

主要方法:

青少年C57BL/6J小鼠从产后日 (PND) 1-14.进行母体分离 (MS).
乙醇消耗被评估使用操作者自我管理和两瓶自由选择范式.
对eCB系统分子 (Cnr1,Faah,Mgll) 的基因表达和神经元激活在包括前额皮质和背状条纹体在内的大脑区域进行了分析.

主要成果:

在初始暴露期间,MS增加了非自愿的乙醇消耗 (PND 28) 并降低了后期操作会话中的歧视指数 (PND 82-86).
在两瓶选择试验中,MS增加了对高度乙醇 (15-20%) 的偏好.
没有发现MS对神经元激活或关键eCB系统基因表达 (Cnr1,Faah) 的显著影响,在背上条纹体,除了Mgll在一个实验.

结论:

早期的生活压力可以改变青少年小鼠的乙醇消费模式.
在这个模型中,内分泌大麻素系统和主要奖励通路中的神经元激活似乎对早期生活压力和青少年乙醇暴露的联合影响具有弹性.
需要进一步的研究来阐明连接早期生活压力,乙醇使用障碍和内分泌系统的确切机制.

关键词:

酒精饮料酒精饮料酒精饮料酒精饮料这是一个CB1受体.在FAAH酶的形成过程中,在这里,Fos Fos Fos Fos Fos Fos.马格尔酶 (MAGL) 是一种酶.压力压力压力压力

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