认知-有氧运动训练对脑衍生的神经营养因子,双重任务能力和多发性硬化症患者的心情状态的影响
Sara Farajnia1, Hamid Rajabi2, Mehran Ghaffari3
1Department of Biological Sciences in Sport, Faculty of Sport Sciences and Health, Shahid Beheshti University, Tehran, Iran.
Physiology & behavior
|November 23, 2024
概括
在多发性硬化症 (MS) 患者中,将有氧运动与激励性单词朗诵 (布莱顿训练) 结合起来,改善了来自大脑的神经营养因子 (BDNF),双重任务性能和情绪.
科学领域:
- 神经科学是一个神经科学.
- 运动生理学 运动生理学
- 康复科学 康复科学 康复科学
背景情况:
- 多发性硬化症 (MS) 由于脱髓化和神经退行而带来显著的身体,认知和情绪挑战.
- 双任务 (DT) 培训对于解决MS中运动和认知功能之间的相互作用至关重要.
- 脑衍生神经营养因子 (BDNF) 是一个关键的生物标志物,与神经健康和可塑性有关.
研究的目的:
- 研究一种新的有氧认知训练计划 (Brythonic) 与单独的有氧训练相比,对MS患者的BDNF水平,DT表现和情绪的影响.
- 评估将精神炼 (背诵激励词) 与身体活动相结合对MS神经和心理结果的影响.
- 为了确定为期10周的家庭在线培训干预措施的有效性.
主要方法:
- 30名复发性复发性多发性硬化症患者 (EDSS < 4) 被随机分为三个组:布莱顿训练,有氧训练和对照组.
- 参与者参加了为期10周的监督,家庭在线培训 (每周2次),包括热身,运动和降温.
- 结果措施包括血清BDNF水平,DT表现 (准确性,响应时间) 和情绪状态 (POMS) 概况,评估干预前后.
主要成果:
- 布莱顿组显示BDNF水平显著增加,而对照组显示BDNF水平有所下降.
- 与有氧和对照组相比,在Brythonic组中观察到DT性能 (精度和响应时间) 的显著改善.
- 在大多数POMS类别中,Brythonic干预导致了显著的情绪改善,而有氧组显示了选择性速度的改善.
结论:
- 综合有氧和认知 (动机性词语朗诵) 训练 (Brythonic) 有效地提高了MS患者的BDNF水平,双重任务能力和情绪状态.
- 将精神挑战与身体活动相结合,为MS患者带来了显著的好处.
- 建议进行更大规模的队列研究,以验证这些有前途的发现,并进一步探索布莱顿训练的治疗潜力.
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