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Daiki Sasabayashi¹, Sakiko Tsugawa², Shinichiro Nakajima³

¹Department of Neuropsychiatry, University of Toyama Graduate School of Medicine and Pharmaceutical Sciences, 2630 Sugitani, Toyama city, Toyama 930-0194, Japan; Research Center for Idling Brain Science, University of Toyama, 2630 Sugitani, Toyama city, Toyama 930-0194, Japan.

Progress in neuro-psychopharmacology & biological psychiatry

|November 23, 2024

概括

患精神病临床高风险的个体表现出改变的大脑结构共变性. 额头-双肩区域的过度旋转可能预测晚期精神病发作,这表明它在脆弱性方面发挥了作用.

科学领域:

神经成像是一种神经成像.
精神病学是一个精神病学.
大脑发育大脑发育

背景情况:

精神分裂症与异常的结构共变性有关,可能反映出大脑成熟和神经进展的改变.
目前尚不清楚这些差异是否存在于临床高危精神病 (ARMS) 个体中,以及它们是否与前兆症状或精神病发作相关.

研究的目的:

在一个大规模的ARMS样本中调查全脑结构共变性模式,结果各不相同.
检查ARMS个体的结构共变性,临床症状和认知障碍之间的关联.

主要方法:

横截面,多中心磁共振成像研究.
在155名ARMS个体和191名健康对照中评估了皮质厚度,面积,体积和旋转的全脑结构共变性.
根据临床随访,ARMS参与者被分类为:精神病发作 (ARMS-P),持续症状或缓解 (ARMS-R).

主要成果:

与对照组相比,ARMS个体显示出明显更高的广泛皮质结构共变性,每个皮质测量都有不同的模式.
皮层区域的结构共变性较高与怀疑和迫害思想有关.
与ARMS-R个体相比,ARMS-P个体表现出明显更高的前额-双肩旋转结构共变.

结论:

改变的结构共变性与精神病脆弱性有关.
在ARMS患者中,过度的大脑转化结构共变可能预测他们的临床过程,并导致精神病的发展.

关键词:

处于危险的精神状态皮层测量皮层测量皮层测量个体差异结构共变性网络的个体差异.磁共振成像技术磁共振成像技术多中心的多中心.结构共变性是指结构的共变性.

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