前COVID和后COVID疫苗接种对长期COVID的影响:系统性审查和元分析
Nick King Ngai Chow1, Charmaine Yuk Wah Tsang1, Yan Hei Chan1
1Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong; Department of Chemical Pathology, The Chinese University of Hong Kong, Hong Kong.
The Journal of infection
|November 23, 2024
概括
两剂量COVID前疫苗接种和一剂量COVID后疫苗接种可能会降低患长期COVID的风险. 疫苗接种提供了一种潜在的策略,通过减轻长期COVID症状来维持生活质量.
科学领域:
- 公共卫生 公共卫生
- 传染性疾病 传染性疾病
- 疫苗学 疫苗学 疫苗学
背景情况:
- 长期的COVID严重影响全球数百万人,降低了生活质量.
- 关于疫苗接种对长期COVID的影响的现有研究缺乏一致的定义.
- 这项研究使用了世卫组织对长期COVID的定义,并分析了疫苗接种时间.
研究的目的:
- 系统地审查和元分析COVID前和COVID后疫苗接种对长期COVID的影响.
- 评估不同疫苗接种计划 (1,2,3剂) 和时间 (感染前或感染后) 的有效性.
主要方法:
- 对25项观察性研究 (14,128,260名参与者) 的系统审查和元分析,截至2024年2月.
- 包括的研究将长期COVID定义为感染后持续3个月以上的症状.
- 使用随机效应模型分析数据,用ROBINS-I评估偏差风险,用GRADE确定证据.
主要成果:
- 两剂量COVID前疫苗接种显示,长期COVID的几率降低了24% (OR=0.76,p=0.001).
- 一次剂量后COVID疫苗接种与15%的几率降低有关 (OR=0.85,p=0.024).
- 一次剂量前COVID疫苗接种没有显著影响 (OR=1.01). 三剂前COVID和两剂后COVID的结果在统计学上是微不足道的.
结论:
- 两剂量COVID前疫苗接种和一剂量COVID后疫苗接种与较低的长期COVID发病率有关.
- 接种疫苗可以作为对长期COVID的保护措施,有助于保持生活质量.
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