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产后早期母亲的压力与人乳微生物组合的变化有关

Hannah G Juncker¹, Rasmus R Jakobsen², Eva F G Naninck³

¹Brain Plasticity Group, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, 1012 WX Amsterdam, the Netherlands; Amsterdam UMC, University of Amsterdam, Vrije Universiteit, Emma Children's Hospital, 1105 AZ Amsterdam, the Netherlands; Amsterdam Reproduction and Development, 1105 AZ Amsterdam, the Netherlands.

Brain, behavior, and immunity

|November 23, 2024

概括

孕产妇的压力会改变早期人乳微生物组的组成. 牛奶微生物组的这些变化可能会影响婴儿肠道殖民和长期健康结果.

科学领域:

微生物组研究的研究.
母婴健康孕产妇和婴儿健康
人类牛奶研究研究.

背景情况:

母亲的压力会对早期发育和健康产生负面影响.
产后母亲的压力会影响母乳的营养成分.
母亲压力对早期人乳微生物群的影响尚不清楚.

研究的目的:

调查产后早期母亲压力与人乳微生物组之间的联系.
为了比较高压和对照组之间的母乳微生物组组成.
为了将母乳微生物组的变化与母亲的压力水平和婴儿特征相关联.

主要方法:

对高压 (n=23) 和对照 (n=69) 组进行前性观察队列研究.
通过问卷评估的母亲压力,头发,唾液和母乳皮质醇.
在第10天和第24天使用16S rRNA测序分析的人类牛奶微生物组.

主要成果:

在高压和对照母亲之间,人乳微生物群β-多样性的显著差异.
高压力母亲的Streptococcus,Gemella,Veillonella的数量减少,Staphylococcus,Corynebacterium,Acinetobacter的数量增加. 这就是为什么我们说.
微生物群多样性与压力,母亲教育和婴儿性别相关,但与牛奶皮质醇无关.

结论:

早期母亲的压力与人乳微生物组的显著改变有关.
这些由压力引起的微生物组变化可能会影响婴儿肠道殖民.
需要进一步的研究来了解对婴儿发育和健康的影响.

关键词:

细菌细菌是一种细菌.母乳是母乳中的一种.哺乳期哺乳期是一个微生物组是一个微生物组.压力压力压力压力

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