开发和评估创新的肠膜囊,用于输送肠直肠特异性水友生物材料
Nicole Fülöpová1, Kateřina Brückner1, Jan Muselík1
1Department of Pharmaceutical Technology, Faculty of Pharmacy, Masaryk University, Brno 612 00, Czech Republic.
International journal of pharmaceutics
|November 23, 2024
概括
新的肠膜囊有效地将生物材料如便微生物种移植 (FMT) 输送到结肠. 这种创新的药物输送系统可以保护消化道中的敏感内容,确保在下胃肠道中有针对性的释放.
科学领域:
- 胃肠病学 胃肠病学
- 药品制造 药品制造 药品制造
- 材料科学 材料科学 材料科学
背景情况:
- 向远部胃肠道 (GIT) 提供向药物对于便微生物种移植 (FMT) 等生物材料至关重要.
- 现有的剂量形式往往无法保护敏感的含量在通过消化系统的过渡过程中免受降解.
研究的目的:
- 设计和评估一种肠膜涂层的硬囊,以有针对性地将生物材料输送到远端GIT.
- 为了确保水友填充物的内部保护,防止在通过消化道时降解.
主要方法:
- 使用的硬凝和DRcapsTM (HPMC和gellan) 囊,内外涂有聚合物涂层.
- 经过测试的乙烯基纤维素,Eudragit® E,聚乙烯酸 (内部) 和Eudragit® S,Acryl-EZE®,酸盐 (外部) 的组合.
- 用于延迟释放剂型的标准分解和修改溶解方法评估的涂层囊.
主要成果:
- 在DRcapsTM上使用内部 (1.0%乙烯基纤维素) 和外部 (20.0%Eudragit® S) 涂层的特定组合实现了结肠释放.
- 囊显示咖啡因释放延迟 (120-720分钟),铁氧化物释放表明破裂 (480分钟后).
- 优化的配方成功地保护了内容,直到目标的结肠释放.
结论:
- 创新和简单的囊涂层显示了针对性药物输送的巨大潜力,特别是对于FMT水悬浮剂,到结肠.
- 施用方法是稳固的,不受涂层数量的影响,并且在标准实验室环境中是可行的.
- 这种方法为针对结肠的药物输送系统提供了实用和有效的解决方案.
相关概念视频
01:16Methods for Studying Drug Absorption: In vitro
203
In vitro experiments are crucial for understanding the transport and absorption of drugs through biological materials. These studies employ varied methods such as the diffusion cell method, the everted sac technique, and the everted ring technique.
The diffusion cell method uses a two-compartment cell, including a donor compartment with the drug solution, which simulates the environment where the drug is applied, and a receptor compartment with a buffer solution, which simulates the environment...
The diffusion cell method uses a two-compartment cell, including a donor compartment with the drug solution, which simulates the environment where the drug is applied, and a receptor compartment with a buffer solution, which simulates the environment...
203
01:28Endoscopic Procedures III: Video Capsule Endoscopy
78
Capsule endoscopy, or wireless or video capsule endoscopy, is a diagnostic procedure for examining the entire gastrointestinal tract. Patients swallow a capsule about the size of a vitamin tablet. The capsule is equipped with a transmitter, a battery, an LED light source, and a color video camera to capture images throughout the gastrointestinal tract. This procedure is particularly useful for diagnosing conditions such as Crohn's disease, ulcerative colitis, tumors, polyps, ulcers,...
78