随机的安慰剂对照试验的triclofos与黑激素的镇静儿童接受睡眠EEG进行睡眠EEG
Priyamol T Mohanan1, Ruchika Jha1, Arjun Kurup1
1Pediatrics, Armed Forces Medical College, Pune, Maharashtra, India.
Archives of disease in childhood
|November 23, 2024
概括
在睡眠剥夺后,克洛福斯和黑激素改善了儿童的睡眠电脑电图 (EEG) 成功率,与安慰剂相比. 特里克洛福斯在成功的睡眠EEG行为方面表现出比黑激素更高的疗效.
科学领域:
- 儿科神经学 儿科神经学
- 睡眠医学 睡眠医学
- 临床试验 临床试验
背景情况:
- 在儿童中进行成功的睡眠电脑电图 (EEG) 可能具有挑战性.
- 睡眠剥夺通常用于促进睡眠EEG,但可能需要辅助.
- 评估药理学药物的疗效,以改善睡眠EEG的成功至关重要.
研究的目的:
- 为了比较黑激素和triclofos的疗效,当添加到睡眠剥夺,与安慰剂对成功的儿童睡眠EEG.
- 评估不同干预条件下的睡眠EEG的成功率.
主要方法:
- 进行了一项双盲,安慰剂对照的随机试验,参与了486名6个月至12岁的儿童.
- 在接受三洛,黑激素或安慰剂之前,参与者经历了25%的睡眠剥夺.
- 主要结局是睡眠EEG的成功进行.
主要成果:
- 与安慰剂 (41%) 相比,使用三洛 (88%) 和黑激素 (76%) 的睡眠脑电图成功率显著更高.
- 特里克洛福斯的成功率明显高于黑色素 (OR=2.2) 和安慰剂 (OR=10.6).
- 三福斯和黑激素之间的不良事件是可比的,没有报告的严重事件.
结论:
- 三洛和黑激素都是睡眠剥夺的有效补充剂,用于在儿童中成功完成睡眠脑电图.
- 特里克洛福斯在睡眠EEG成功方面比黑激素更有效,而不会增加不良事件.
- 这些发现支持在儿科睡眠研究中使用三洛和黑激素.
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